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dc.contributor.authorSILVA, J. M. dapt_BR
dc.contributor.authorGIACHETTO, P. F.pt_BR
dc.contributor.authorSILVA, L. O. dapt_BR
dc.contributor.authorCINTRA, L. C.pt_BR
dc.contributor.authorPAIVA, S. R.pt_BR
dc.contributor.authorYAMAGISHI, M. E. B.pt_BR
dc.contributor.authorCAETANO, A. R.pt_BR
dc.date.accessioned2016-06-22T11:11:11Zpt_BR
dc.date.available2016-06-22T11:11:11Zpt_BR
dc.date.created2016-06-22pt_BR
dc.date.issued2016pt_BR
dc.identifier.citationBMC Genomics, London, v. 17, p. 1-14, 2016.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1047683pt_BR
dc.descriptionBackground: Copy number variations (CNVs) have been shown to account for substantial portions of observed genomic variation and have been associated with qualitative and quantitative traits and the onset of disease in a number of species. Information from high-resolution studies to detect, characterize and estimate population-specific variant frequencies will facilitate the incorporation of CNVs in genomic studies to identify genes affecting traits of importance. Results: Genome-wide CNVs were detected in high-density single nucleotide polymorphism (SNP) genotyping data from 1,717 Nelore (Bos indicus) cattle, and in NGS data from eight key ancestral bulls. A total of 68,007 and 12,786 distinct CNVs were observed, respectively. Cross-comparisons of results obtained for the eight resequenced animals revealed that 92 % of the CNVs were observed in both datasets, while 62 % of all detected CNVs were observed to overlap with previously validated cattle copy number variant regions (CNVRs). Observed CNVs were used for obtaining breed-specific CNV frequencies and identification of CNVRs, which were subsequently used for gene annotation. A total of 688 of the detected CNVRs were observed to overlap with 286 non-redundant QTLs associated with important production traits in cattle. All of 34 CNVs previously reported to be associated with milk production traits in Holsteins were also observed in Nelore cattle. Comparisons of estimated frequencies of these CNVs in the two breeds revealed 14, 13, 6 and 14 regions in high (>20 %), low (<20 %) and divergent (NEL > HOL, NEL < HOL) frequencies, respectively. Conclusions: Obtained results significantly enriched the bovine CNV map and enabled the identification of variants that are potentially associated with traits under selection in Nelore cattle, particularly in genome regions harboring QTLs affecting production traits.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectBioinformáticapt_BR
dc.subjectPolimorfismo de nucleotídeo únicopt_BR
dc.subjectGenotipagempt_BR
dc.subjectCopy number variationspt_BR
dc.subjectSNP genotypingpt_BR
dc.titleGenome-wide copy number variation (CNV) detection in Nelore cattle reveals highly frequent variants in genome regions harboring QTLs affecting production traits.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2016-06-22T11:11:11Zpt_BR
dc.subject.thesagroGado de cortept_BR
dc.subject.nalthesaurusBioinformaticspt_BR
dc.subject.nalthesaurusBeef cattlept_BR
dc.subject.nalthesaurusSingle nucleotide polymorphismpt_BR
dc.subject.nalthesaurusHigh-throughput nucleotide sequencingpt_BR
dc.subject.nalthesaurusGenotypingpt_BR
riaa.ainfo.id1047683pt_BR
riaa.ainfo.lastupdate2016-06-22pt_BR
dc.identifier.doi10.1186/s12864-016-2752-9pt_BR
dc.contributor.institutionJOAQUIM MANOEL DA SILVA, Unemat, IB/Unicamp; POLIANA FERNANDA GIACHETTO, CNPTIA; LUIZ OTAVIO CAMPOS DA SILVA, CNPGC; LEANDRO CARRIJO CINTRA, CNPTIA; SAMUEL REZENDE PAIVA, SRI; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; ALEXANDRE RODRIGUES CAETANO, Cenargen.pt_BR
Aparece en las colecciones:Artigo em periódico indexado (CNPTIA)

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