Título:	Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
Autor:	BIGI, M. M. BLANCO, F. C. ARAUJO, F. R. THACKER, T. C. ZUMÁRRAGA, M. J. CATALDI, A. A. SORIA, M. A. BIGI, F.
Afiliación:	María M. Bigi, School of Agronomy - UBA; Federico Carlos Blanco, Biotechnology Institute/National Institute of Agricultural Technology - INTA; FLABIO RIBEIRO ARAUJO, CNPGC; Tyler C. Thacker, United States Department of Agriculture/Agricultural Research Service/National Animal Disease Center; Martín J. Zumárraga, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Angel A. Cataldi, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Marcelo A. Soria, School of Agronomy - UBA; Fabiana Bigi, Biotechnology Institute/National Institute of Agricultural Technology - INTA.
Año:	2016
Referencia:	Microbiology and Immunology, v. 60, n. 8, p. 552-560, August 2016
Descripción:	Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over>99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
Thesagro:	Polimorfismo Anoxia Mycobacterium Bovis
NAL Thesaurus:	Mycobacterium tuberculosis Polymorphism
Palabras clave:	Regulator
Tipo de Material:	Artigo de periódico
Acceso:	openAccess
Aparece en las colecciones:	Artigo em periódico indexado (CNPGC)