Título:	Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere.
Autor:	ABRAHÃO, J. SILVA, L. SILVA, L. S. KHALIL, J. Y. B RODRIGUES, R. ARANTES, T. ASSIS, F. BORATTO, P. ANDRADE, M. KROON, E. G. RIBEIRO, B. BERGIER, I. SELIGMANN, H. GHIGO, E. COLSON, P. LEVASSEUR, A. KROEMER, G. RAOULT, D. LA SCOLA, B.
Afiliación:	JÔNATAS ABRAHÃO, Universidade Federal de Minas Gerais; LORENA SILVA, Universidade Federal de Minas Gerais; LUDMILA SANTOS SILVA, Universidade Federal de Minas Gerais; JACQUES YAACOUB BOU KHALIL, CNRS, 13005 Marseille; RODRIGO RODRIGUES, Universidade Federal de Minas Gerais; THALITA ARANTES, Universidade Federal de Minas Gerais; FELIPE ASSIS, Universidade Federal de Minas Gerais; PAULO BORATTO, Universidade Federal de Minas Gerais; MIGUEL ANDRADE, Universidade de Brasília; ERNA GEESSIEN KROON, Universidade Federal de Minas Gerais; BERGMANN RIBEIRO, Universidade de Brasília; IVAN BERGIER TAVARES DE LIMA, CPAP; HERVE SELIGMANN, Aix Marseille Univ; ERIC GHIGO, Aix Marseille Univ; PHILIPPE COLSON, Aix Marseille Univ; ANTHONY LEVASSEUR, Aix Marseille Univ; GUIDO KROEMER, Gustave Roussy Cancer Campus; DIDIER RAOULT, Aix Marseille Univ; BERNARD LA SCOLA, Aix Marseille Univ.
Año:	2018
Referencia:	Nature Communications, v. 9, n. 749, p. 1-12, 2018.
Descripción:	Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44?1.51 Mb linear double-strand DNA coding for 1276?1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.
Thesagro:	Virus
NAL Thesaurus:	Viruses
DOI:	10.1038/s41467-018-03168-1
Tipo de Material:	Artigo de periódico
Acceso:	openAccess
Aparece en las colecciones:	Artigo em periódico indexado (CPAP)