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dc.contributor.authorSOUZA, M. M. de
dc.contributor.authorZERLOTINI NETO, A.
dc.contributor.authorGEISTLINGER, L.
dc.contributor.authorTIZIOTO, P. C.
dc.contributor.authorTAYLOR, J. F.
dc.contributor.authorROCHA, M. I. P.
dc.contributor.authorDINIZ, W. J. S.
dc.contributor.authorCOUTINHO, L. L.
dc.contributor.authorREGITANO, L. C. de A.
dc.date.accessioned2019-01-09T23:49:48Z-
dc.date.available2019-01-09T23:49:48Z-
dc.date.created2018-12-11
dc.date.issued2018
dc.identifier.citationScientific Reports, v.8, n.13747, p.1-12, jan. 2018.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1101203-
dc.descriptionTranscription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectDNA bovine
dc.subjectGene expression in cattle
dc.titleA comprehensive manually-curated compendium of bovine transcription factors.
dc.typeArtigo de periódico
dc.date.updated2019-01-09T23:49:48Zpt_BR
dc.subject.nalthesaurusGene expression regulation
riaa.ainfo.id1101203
riaa.ainfo.lastupdate2019-01-09
dc.identifier.doi10.1038/s41598-018-32146-2
dc.contributor.institutionMarcela M. de Souza, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; Ludwig Geistlinger, FAPESP; Polyana C. Tizioto, NGS Genomic Solution; Jeremy F. Taylor, University of Missouri; Marina I. P. Rocha, UFSCar; Wellison J. S. Diniz, UFSCar; Luiz L. Coutinho, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Aparece en las colecciones:Artigo em periódico indexado (CPPSE)

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