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dc.contributor.authorSOUZA, M. M. de
dc.contributor.authorZERLOTINI NETO, A.
dc.contributor.authorGEISTLINGER, L.
dc.contributor.authorTIZIOTO, P. C.
dc.contributor.authorTAYLOR, J. F.
dc.contributor.authorROCHA, M. I. P.
dc.contributor.authorDINIZ, W. J. S.
dc.contributor.authorCOUTINHO, L. L.
dc.contributor.authorREGITANO, L. C. de A.
dc.contributor.otherMarcela M. de Souza, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; Ludwig Geistlinger, FAPESP; Polyana C. Tizioto, NGS Genomic Solution; Jeremy F. Taylor, University of Missouri; Marina I. P. Rocha, UFSCar; Wellison J. S. Diniz, UFSCar; Luiz L. Coutinho, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
dc.descriptionTranscription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
dc.publisherScientific Reports, v.8, n.13747, p.1-12, jan. 2018.
dc.relation.ispartofEmbrapa Pecuária Sudeste - Artigo em periódico indexado (ALICE)
dc.subjectDNA bovine
dc.subjectGene expression in cattle
dc.titleA comprehensive manually-curated compendium of bovine transcription factors.
dc.typeArtigo em periódico indexado (ALICE)
dc.subject.nalthesaurusGene expression regulation
Appears in Collections:Artigo em periódico indexado (CPPSE)

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