Title:	A comprehensive manually-curated compendium of bovine transcription factors.
Authors:	SOUZA, M. M. de ZERLOTINI NETO, A. GEISTLINGER, L. TIZIOTO, P. C. TAYLOR, J. F. ROCHA, M. I. P. DINIZ, W. J. S. COUTINHO, L. L. REGITANO, L. C. de A.
Affiliation:	Marcela M. de Souza, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; Ludwig Geistlinger, FAPESP; Polyana C. Tizioto, NGS Genomic Solution; Jeremy F. Taylor, University of Missouri; Marina I. P. Rocha, UFSCar; Wellison J. S. Diniz, UFSCar; Luiz L. Coutinho, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Date Issued:	2018
Citation:	Scientific Reports, v.8, n.13747, p.1-12, jan. 2018.
Description:	Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
NAL Thesaurus:	Gene expression regulation
Keywords:	DNA bovine Gene expression in cattle
DOI:	10.1038/s41598-018-32146-2
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPPSE)