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|Research center of Embrapa/Collection:||Embrapa Informática Agropecuária - Artigo em periódico indexado (ALICE)|
|Type of Material:||Artigo em periódico indexado (ALICE)|
|Authors:||OLIVEIRA, P. S. N. de|
COUTINHO, L. L.
CESAR, A. S. M.
DINIZ, W. J. da S.
SOUZA, M. de S.
ANDRADE, B. G.
KOLTES, J. E.
MOURÃO, G. B.
ZERLOTINI NETO, A.
REECY, J. M.
REGITANO, L. C. de A.
|Additional Information:||PRISCILA S. N. DE OLIVEIRA, CPPSE; LUIZ L. COUTINHO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP; WELLISON J. DA SILVA DINIZ, UFSCar; MARCELA M. DE SOUZA, Iowa State University; BRUNO G. ANDRADE, CPPSE; JAMES E. KOLTES, Iowa State University; GERSON B. MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.|
|Title:||Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle.|
|Publisher:||Frontiers in Genetics, v. 10, p. 1-14, July 2019.|
|Notes:||Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.|
|Keywords:||Ácido linoleico conjugado|
Redes de co-expressão
|Description:||Fatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption.|
Gado de Corte
|NAL Thesaurus:||Beef cattle|
Conjugated linoleic acid
|Appears in Collections:||Artigo em periódico indexado (CNPTIA)|