Title:	Extreme-QTL mapping of monepantel resistance in Haemonchus contortus.
Authors:	NICIURA, S. C. M. TIZIOTO, P. C. MORAES, C. V. CRUVINEL, G. G. ALBUQUERQUE, A. C. A. de SANTANA, R. C. M. CHAGAS, A. C. de S. ESTEVES, S. N. BENAVIDES, M. V. AMARANTE, A. F. T. do
Affiliation:	SIMONE CRISTINA MEO NICIURA, CPPSE; Polyana Cristine Tizioto, NGS Soluções Genômicas; Caroline Valério Moraes, UFSCar; Giovanna Gabrielle Cruvinel, UNICEP; Ana Cláudia Alexandre de Albuquerque, FMVZ-UNESP; RAUL COSTA MASCARENHAS SANTANA, CPPSE; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; MAGDA VIEIRA BENAVIDES, CPPSUL; Alessandro Francisco Talamini do Amarante, IBB-UNESP.
Date Issued:	2019
Citation:	Parasites Vectors, v.12, n.403, p.1-11, 2019.
Description:	Haemonchus contortus, a gastrointestinal nematode parasite of sheep, is mainly controlled by anthelmintics; the occurrence of anthelmintic resistance leads to treatment failures and increases economic burden. Because molecular mechanisms involved in drug resistance can be elucidated by genomic studies, an extreme quantitative trait locus (X-QTL) mapping approach was used to identify co-segregation of the resistance phenotype with genetic markers to detect the genome-wide variants associated with monepantel resistance in H. contortus.
NAL Thesaurus:	Drug resistance
Keywords:	Anthelmintic resistance Genome sequencing Sheep gastrointestinal nematodes F2 mapping
DOI:	https://doi.org/10.1186/s13071-019-3663-9
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPPSE)