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dc.contributor.authorGUEDES, J. A. C.eng
dc.contributor.authorALVES FILHO, E. DE G.eng
dc.contributor.authorSILVA, M. F. S.eng
dc.contributor.authorRODRIGUES, T. H. S.eng
dc.contributor.authorRAMIRES, C. M. C.eng
dc.contributor.authorLIMA, M. A. C. deeng
dc.contributor.authorSILVA, G. S. DAeng
dc.contributor.authorPESSOA, C. DO Óeng
dc.contributor.authorCANUTO, K. M.eng
dc.contributor.authorBRITO, E. S. deeng
dc.contributor.authorALVES, R. E.eng
dc.contributor.authorNASCIMENTO, R. F. DOeng
dc.contributor.authorZOCOLO, G. J.eng
dc.date.accessioned2020-02-13T18:16:16Z-
dc.date.available2020-02-13T18:16:16Z-
dc.date.created2020-02-13
dc.date.issued2020
dc.identifier.citationJournal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.eng
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219-
dc.descriptionAgroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compoundseng
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectMetabolômicaeng
dc.subjectResiduo agroindustrialeng
dc.subjectAgroindustriaeng
dc.subjectCo-produtoeng
dc.titleGC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.eng
dc.typeArtigo de periódicoeng
dc.date.updated2020-04-17T11:11:11Z
dc.subject.thesagroSpondias Mombineng
dc.subject.thesagroUmbueng
dc.subject.thesagroCromatografiaeng
dc.subject.nalthesaurusYellow mombinseng
dc.subject.nalthesaurusChromatographyeng
dc.subject.nalthesaurusMetabolomicseng
dc.subject.nalthesaurusSpondiaseng
dc.format.extent2p. 331-340eng
riaa.ainfo.id1120219eng
riaa.ainfo.lastupdate2020-04-17 -03:00:00
dc.identifier.doi10.21577/0103-5053.20190185eng
dc.contributor.institutionJHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Cearáeng
dc.contributor.institutionELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria Tropicaleng
dc.contributor.institutionMARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Cearáeng
dc.contributor.institutionTIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, Sobraleng
dc.contributor.institutionCHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA)eng
dc.contributor.institutionMARIA AUXILIADORA COELHO DE LIMA, CPATSAeng
dc.contributor.institutionGISELE SILVESTRE DA SILVA, Embrapa Agroindústria Tropicaleng
dc.contributor.institutionCLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Cearáeng
dc.contributor.institutionKIRLEY MARQUES CANUTO, CNPATeng
dc.contributor.institutionEDY SOUSA DE BRITO, CNPATeng
dc.contributor.institutionRICARDO ELESBAO ALVES, CNATeng
dc.contributor.institutionRONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Cearáeng
dc.contributor.institutionGUILHERME JULIAO ZOCOLO, CNPAT.eng
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