Title:	GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
Authors:	GUEDES, J. A. C. ALVES FILHO, E. DE G. SILVA, M. F. S. RODRIGUES, T. H. S. RAMIRES, C. M. C. LIMA, M. A. C. de SILVA, G. S. DA PESSOA, C. DO Ó CANUTO, K. M. BRITO, E. S. de ALVES, R. E. NASCIMENTO, R. F. DO ZOCOLO, G. J.
Affiliation:	JHONYSON ARRUDA CARVALHO GUEDES, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará ELENILSON DE GODOY ALVES FILHO, Embrapa Agroindústria Tropical MARIA FRANCILENE SOUZA SILVA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará TIGRESSA HELENA SOARES RODRIGUES, Universidade Estadual do Vale do Acaraú, Sobral CHRISTIANE MENDES CASSIMIRO RAMIRES, Empresa Estadual de Pesquisa Agropecuária da Paraíba (EMEPA) MARIA AUXILIADORA COELHO DE LIMA, CPATSA GISELE SILVESTRE DA SILVA, Embrapa Agroindústria Tropical CLAUDIA DO Ó PESSOA, Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará KIRLEY MARQUES CANUTO, CNPAT EDY SOUSA DE BRITO, CNPAT RICARDO ELESBAO ALVES, CNAT RONALDO FERREIRA DO NASCIMENTO, Departamento de Química Analítica e Físico-Química, Universidade Federal do Ceará GUILHERME JULIAO ZOCOLO, CNPAT.
Date Issued:	2020
Citation:	Journal of the Brazilian Chemical Society, Campinas, v. 31, n. 2, p. 331-340, 2020.
Pages:	p. 331-340
Description:	Agroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds
Thesagro:	Spondias Mombin Umbu Cromatografia
NAL Thesaurus:	Yellow mombins Chromatography Metabolomics Spondias
Keywords:	Metabolômica Residuo agroindustrial Agroindustria Co-produto
DOI:	10.21577/0103-5053.20190185
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPATSA)