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dc.contributor.authorFRAUCHES, N. S.
dc.contributor.authorMONTENEGRO, J.
dc.contributor.authorAMARAL, T.
dc.contributor.authorABREU, J. P.
dc.contributor.authorLAIBER, G.
dc.contributor.authorJORGE JUNIOR
dc.contributor.authorBORGUINI, R. G.
dc.contributor.authorSANTIAGO, M. C. P. de A.
dc.contributor.authorPACHECO, S.
dc.contributor.authorNAKAJIMA, V. M.
dc.contributor.authorGODOY, R. L. de O.
dc.contributor.authorTEODORO, A. J.
dc.date.accessioned2021-01-30T00:53:44Z-
dc.date.available2021-01-30T00:53:44Z-
dc.date.created2021-01-27
dc.date.issued2021
dc.identifier.citationMolecules, v. 26, n. 564 , 2021. p. 1-16.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1129588-
dc.descriptionThere is a significant indication of the beneficial health effects of fruit rich diets. Fruitsof native plant species have noticeably different phytochemicals and bioactive effects. The aim ofthis work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ),jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and theirinfluence on antioxidant activityin vitroand antiproliferative effects on human colon adenocarci-noma cells. According to the results, dried peel powders (DP) have a high anthocyanin content,phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD).M.jaboticabadried peel powder extract had a higher total anthocyanin and phenolic compounds content(802.90±1.93 and 2152.92±43.95 mg/100 g, respectively). A reduction in cell viability of HT-29cells after treatment withM. jaboticabaextracts (DP-MJ and FD-MJ) was observed via MTT assay.Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SMhad an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cellsin relation to the control group. The findings of this study highlight the potential of peel powdersfromMyrtaceaefruits as an important source of natural antioxidants and a protective effect againstcolon adenocarcinoma
dc.language.isoeng
dc.rightsopenAccesseng
dc.subjectColon cancereng
dc.subjectMalay-appleeng
dc.subjectJamun-berryeng
dc.subjectMyrtaceae fruitseng
dc.titleAntiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family.
dc.typeArtigo de periódico
dc.subject.thesagroJabuticaba
dc.subject.nalthesaurusBioactive compoundseng
riaa.ainfo.id1129588
riaa.ainfo.lastupdate2021-02-01 -02:00:00
dc.identifier.doihttps://doi.org/10.3390/molecules26030564
dc.contributor.institutionNayara Simas Frauches, UNIRIO
dc.contributor.institutionJúlia Montenegro, UNIRIOeng
dc.contributor.institutionThuane Amaral, UNIRIOeng
dc.contributor.institutionJoel Pimentel Abreu, UNIRIOeng
dc.contributor.institutionGabriela Laiber, UNIRIOeng
dc.contributor.institutionJorge Junior, UFRJeng
dc.contributor.institutionRENATA GALHARDO BORGUINI, CTAAeng
dc.contributor.institutionMANUELA CRISTINA P DE A SANTIAGO, CTAAeng
dc.contributor.institutionSIDNEY PACHECO, CTAAeng
dc.contributor.institutionVania Mayumi Nakajima, UFFeng
dc.contributor.institutionRONOEL LUIZ DE OLIVEIRA GODOY, CTAAeng
dc.contributor.institutionAnderson Junger Teodoro, UNIRIO.eng
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