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http://www.alice.cnptia.embrapa.br/alice/handle/doc/1135728
Título: | Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth. |
Autoria: | OLIVEIRA, E. R. FAYER, L. ZANETTE, R. S. S. LADEIRA, L. O. OLIVEIRA, L. F. C. de MARANDUBA, C. M. C. BRANDAO, H. de M. MUNK, M. |
Afiliação: | EDUARDA R. OLIVEIRA, Universidade Federal de Juiz de Fora; LEONARA FAYER, Universidade Federal de Juiz de Fora; RAFAELLA S. S. ZANETTE, Universidade Federal de Juiz de Fora; LUIZ O. LADEIRA, Universidade Federal de Minas Gerais; LUIZ F. C. DE OLIVEIRA, Universidade Federal de Juiz de Fora; CARLOS M. C. MARANDUBA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora. |
Ano de publicação: | 2022 |
Referência: | Nanotechnology, v. 33, n. 6, 065101, 2022. |
Conteúdo: | Carboxylated Multi-wall Carbon Nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNTCOOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields. |
Thesagro: | Carbono |
Palavras-chave: | Nanotecnologia Estudo in vitro Engenharia de tecido Células-tronco |
Digital Object Identifier: | https://doi.org/10.1088/1361-6528/ac335b |
Tipo do material: | Artigo de periódico |
Acesso: | openAccess |
Aparece nas coleções: | Artigo em periódico indexado (CNPGL) |
Arquivos associados a este item:
Arquivo | Tamanho | Formato | |
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Cytocompatibility-of-carboxylated-multi-wall-carbon-nanotubes-in-stem-cells-.pdf | 865,19 kB | Adobe PDF | Visualizar/Abrir |