Title:	Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
Authors:	PETRÔNIO, M. S. BARROS-ALEXANDRINO, T. T. LIMA, A. M. F. ASSIS, O. B. G. de INOUE-NAGATA, A. K. NAKASU, E. Y. T. TIERA, M. J. PILON, L.
Affiliation:	MAICON S. PETRÔNIO, UNESP TAIS T. BARROS-ALEXANDRINO ALINE M. F. LIMA, UNESP ODILIO BENEDITO GARRIDO DE ASSIS, CNPDIA ALICE KAZUKO INOUE NAGATA, CNPH ERICH YUKIO TEMPEL NAKASU, CNPH MARCIO J. TIERA, UNESP LUCIMEIRE PILON, CNPH.
Date Issued:	2022
Citation:	Biointerface Research in Applied Chemistry, v. 12, n. 4, p. 5266-5279, 2022.
Description:	Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.
NAL Thesaurus:	Tomato mosaic virus Double-stranded RNA Lettuce RNA interference
ISSN:	2069-5837
DOI:	https://doi.org/10.33263/BRIAC124.52665279
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPH)