Título:	Physicochemical and toxicity investigation of chitosan-based dsRNA nanocarrier formation.
Autor:	PETRÔNIO, M. S. BARROS-ALEXANDRINO, T. T. LIMA, A. M. F. ASSIS, O. B. G. de INOUE-NAGATA, A. K. NAKASU, E. Y. T. TIERA, M. J. PILON, L.
Afiliación:	MAICON S. PETRÔNIO, UNESP TAIS T. BARROS-ALEXANDRINO ALINE M. F. LIMA, UNESP ODILIO BENEDITO GARRIDO DE ASSIS, CNPDIA ALICE KAZUKO INOUE NAGATA, CNPH ERICH YUKIO TEMPEL NAKASU, CNPH MARCIO J. TIERA, UNESP LUCIMEIRE PILON, CNPH.
Año:	2022
Referencia:	Biointerface Research in Applied Chemistry, v. 12, n. 4, p. 5266-5279, 2022.
Descripción:	Thus, the present study is focused on the chitosan-dsRNA interactions and the physicochemical properties of the dsRNA-loaded nanoparticles, including cytotoxicity and hemolysis assays. dsRNA molecules homologous to a partial genome of the phytopathogenic tomato mosaic virus (ToMV) were used as the model virus. The combination of chitosan's antimicrobial properties and its delivery capability provides a potential for ds-RNA-nanoparticles to deliver dsRNA as a tool for virus disease control in crops.
NAL Thesaurus:	Tomato mosaic virus Double-stranded RNA Lettuce RNA interference
ISSN:	2069-5837
DOI:	https://doi.org/10.33263/BRIAC124.52665279
Tipo de Material:	Artigo de periódico
Acceso:	openAccess
Aparece en las colecciones:	Artigo em periódico indexado (CNPH)