Título:	Effect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases.
Autoria:	FANALLI, S. L. SILVA, B. P. M. DA GOMES, J. D. CICONELLO, F. N. ALMEIDA, V. V. DE FREITAS, F. A. O. MOREIRA, G. C. M. VIGNATO, B. S. AFONSO, J. REECY, J. KOLTES, J. KOLTES, D. REGITANO, L. C. de A. BAILEIRO, J. C. DE C. FREITAS, L. COUTINHO, L. L. FUKUMASU, H. ALENCAR, S. M. DE LUCHIARI FILHO, A. CESAR, A. S. M.
Afiliação:	SIMARA LARISSA FANALLI, University of São Paulo BRUNA PEREIRA MARTINS DA SILVA, University of São Paulo JULIA DEZEN GOMES, University of São Paulo FERNANDA NERY CICONELLO, University of São Paulo VIVIAN VEZZONI DE ALMEIDA, Federal University of Goiás FELIPE ANDRÉ OLIVEIRA FREITAS, University of São Paulo GABRIEL COSTA MONTEIRO MOREIRA, University of Liège BÁRBARA SILVA-VIGNATO, University of São Paulo JULIANA AFONSO, University Federal of São Carlos JAMES REECY, Iowa State University JAMES KOLTES, Iowa State University DAWN KOLTES, Iowa State University LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE JÚLIO CESAR DE CARVALHO BAILEIRO, University of São Paulo LUCIANA FREITAS, DB Genética de Suínos LUIZ LEHMANN COUTINHO, University of São Paulo HEIDGE FUKUMASU, University of São Paulo SEVERINO MATIAS DE ALENCAR, University of São Paulo ALBINO LUCHIARI FILHO, University of São Paulo ALINE SILVA MELLO CESAR, University of São Paulo.
Ano de publicação:	2022
Referência:	Scientific Reports, v. 12, 10318, jun. 2022.
Páginas:	10 p.
Conteúdo:	Dietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. However, the consumers still associate dietary FA with fat deposition and increased occurrence of metabolic diseases such as obesity and atherosclerosis. Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA, EGFR, and SREBP2 precursor. These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. It could contribute to nutrigenomics research field that aims to elucidate dietary interventions in animal and human health, as well as to drive food technology and science.
NAL Thesaurus:	Nutrigenomics Lipid metabolism
Palavras-chave:	Lipid homeostasis Transcriptome profile of animal models Human metabolic diseases Dietary interventions Dietary fatty acids Dietary FA on metabolic diseases
Digital Object Identifier:	https://doi.org/10.1038/s41598-022-14069-1
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CPPSE)