Title:	Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine.
Authors:	FERREIRA, F. V. SOUZA, A. G. AJDARY, R. SOUZA, L. P. de LOPES. J. H. CORREA, D. S. SIQUEIRA, G. BARUD, H. S. ROSA, D. S. MATTOSO, L. H. C. ROJAS, O. J.
Affiliation:	LNNA Embrapa Instrumentação; Federal University of ABC, Santo André; Aalto University, Aalto, Espoo, Finland; Aston Institute of Materials Research, Aston University, Birmingham, UK; Technological Institute of Aeronautics (ITA), Sao Jose dos Campos, SP, Brazil; DANIEL SOUZA CORREA, CNPDIA; Empa - Swiss Federal Laboratories for Materials Science and Technology, Überlandstrasse 129, 8600, Dübendorf, S; University of Araraquara (UNIARA), Araraquara; Federal University of ABC (UFABC), Santo André, Brazil; LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA; The University of British Columbia, 2360 East Mall, Vancouver, BC.
Date Issued:	2023
Citation:	Bioactive Materials, v. 29, 2023.
Pages:	151 - 176
Description:	We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure?property?function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.
Keywords:	Regenerative medicine Biomaterial Sustainable materials Green nanomaterials
ISSN:	2452-199X
DOI:	https://doi.org/10.1016/j.bioactmat.2023.06.020
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPDIA)