Título:	PK/PD integration for intramuscular dose determination of intramuscular sodium cloxacillin for infections caused by Staphylococcus spp in goat.
Autoria:	FELIX, L. A. GONZAGA, L. W. F. SOARES, B. C. F. SUÁREZ, G. BRANDAO, H. de M. FACCIOLI-MARTINS, P. Y. FERRANTE, M.
Afiliação:	UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDADE FEDERAL DE LAVRAS; UNIVERSIDAD DE LA REPÚBLICA DE MONTEVIDEO; HUMBERTO DE MELLO BRANDAO, CNPGL; PATRICIA YOSHIDA FACCIOLI MARTINS, CNPC; UNIVERSIDADE FEDERAL DE LAVRAS.
Ano de publicação:	2023
Referência:	Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 75, n. 6, p. 1087-1096, 2023.
Conteúdo:	This study aims to determine therapeutic protocols of intramuscular sodium cloxacillin (IM) in goats with potential antibacterial effects against Staphylococcus spp. We constructed a pharmacokinetic (PK) model of IM, followed by a pharmacokinetic/pharmacodynamic integration (PK/PD). Simulations of different therapeutic protocols were then performed, with the doses ranging from 30 to100 mg/kg every 8, 12, or 24 hours. We calculated the probability to target attainment (PTA) of reach protocol's therapeutic according to the minimum inhibitory concentration (MIC) range of 0.06 to 4 μg/mL. The PK/PD index (PDT) used was "time above the MIC for 40% of the time" (T>MIC ≥40%). Protocols with single administration per day were incapable of achieving PTA ≥ 90% for any of the estimated MICs. However, by decreasing the administration interval, the PTA was increased. Thus, from the dose of 50 mg/kg every 12 hours, a PTA≥ 90% for MICs ≤ 0.5 μg/mL was achieved, while the 30 mg/kg dose every 8 hours was able to achieve a PTA≥ 90% for MICs of 2 μg/mL. The results suggest using 30 mg/kg dose every 8 hours in clinical studies of agents with MICs ≤ 2μg/mL; Nevertheless, the practitioner should adjust the dose in severe patients.
Thesagro:	Caprino
Palavras-chave:	Antibioticoterapia Sepse Farmacometria Modelo translacional Simulação de Monte Carlo Antibiotic therapy
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPGL)