Título:	A symbiotic meal containing extruded sorghum and probiotic (Bifidobacterium longum) ameliorated intestinal health markers in individuals with chronic kidney disease: a secondary analysis of a subsample from a previous randomized and controlled clinical trial.
Autoria:	LÚCIO, H. G. LOPES, R. de C. S. O. GOMES, M. J. C. SILVA, A. da GRANCIERI, M. DELLA LUCIA, C. M. QUEIROZ, V. A. V. SILVA, B. F. da MARTINO, H. S. D.
Afiliação:	HAIRA GUEDES LÚCIO, UNIVERSIDADE FEDERAL DE VIÇOSA; RITA DE CASSIA STAMPINI OLIVEIRA LOPES, UNIVERSIDADE FEDERAL DE VIÇOSA; MARIANA JUSTE CONTIN GOMES, UNIVERSIDADE FEDERAL DE VIÇOSA; ALESSANDRA DA SILVA, UNIVERSIDADE FEDERAL DE VIÇOSA; MARIANA GRANCIERI, UNIVERSIDADE FEDERAL DO ESPÍRITO SANTO; CERES MATTOS DELLA LUCIA, UNIVERSIDADE FEDERAL DE VIÇOSA; VALERIA APARECIDA VIEIRA QUEIROZ, CNPMS; BÁRBARA PEREIRA DA SILVA, UNIVERSIDADE FEDERAL DE VIÇOSA; HERCIA STAMPINI DUARTE MARTINO, UNIVERSIDADE FEDERAL DE VIÇOSA.
Ano de publicação:	2024
Referência:	Nutrients, v. 16, 1852, 2024.
Conteúdo:	Background: Chronic kidney disease increases uremic toxins concentrations, which have been associated with intestinal dysbiosis. Sorghum bicolor L. Moench has dietary fiber and bioactive compounds, while Bifidobacterium longum can promote beneficial health effects. Methods: It is a controlled, randomized, and single-blind clinical trial. Thirty-nine subjects were randomly separated into two groups: symbiotic group (SG), which received 100 mL of unfermented probiotic milk with Bifidobacterium longum strain and 40 g of extruded sorghum flakes; and the control group (CG), which received 100 mL of pasteurized milk and 40 g of extruded corn flakes for seven weeks. Results: The uremic toxins decreased, and gastrointestinal symptoms improved intragroup in the SG group. The acetic, propionic, and butyric acid production increased intragroup in the SG group. Regarding α-diversity, the Chao1 index was enhanced in the SG intragroup. The KEGG analysis revealed that symbiotic meal increased the intragroup energy and amino sugar metabolism, in addition to enabling essential amino acid production and metabolism, sucrose degradation, and the biosynthesis of ribonucleotide metabolic pathways. Conclusions: The consumption of symbiotic meal reduced BMI, improved short-chain fatty acid (SCFA) synthesis and gastrointestinal symptoms, increased diversity according to the Chao1 index, and reduced uremic toxins in chronic kidney disease patients.
Thesagro:	Sorgo Sorghum Bicolor
Palavras-chave:	Refeição simbiótica Microbiota intestinal Toxinas urêmicas Symbiotic meal Gut microbiota SCFAs Uremic toxins
Digital Object Identifier:	https://doi.org/10.3390/nu16121852
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPMS)