Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1166133
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dc.contributor.authorSANTOS, V. H. P. dos
dc.contributor.authorANDRE, R. S.
dc.contributor.authorANJOS, J. P. dos
dc.contributor.authorMERCANTE, L. A.
dc.contributor.authorCORREA, D. S.
dc.contributor.authorSILVA, E. O.
dc.date.accessioned2024-07-31T19:56:55Z-
dc.date.available2024-07-31T19:56:55Z-
dc.date.created2024-07-31
dc.date.issued2024
dc.identifier.citationFolia Microbiologica, v. 69, 2024.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1166133-
dc.descriptionAbstract Biotransformation of steroids by fungi has been raised as a successful, eco-friendly, and cost-effective biotechnological alternative for chemical derivatization. Endophytic fungi live inside vegetal tissues without causing damage to the host plant, making available unique enzymes that carry out uncommon reactions. Moreover, using nanofibrous membranes as support for immobilizing fungal cells is a powerful strategy to improve their performance by enabling the combined action of adsorption and transformation processes, along with increasing the stability of the fungal cell. In the present study, we report the use of polyacrylonitrile nanofibrous membrane (PAN NFM) produced by electrospinning as supporting material for immobilizing the endophytic fungus Penicillium citrinum H7 aiming the biotransformation of progesterone. The PAN@ H7 NFM displayed a high progesterone transformation efficiency (above 90%). The investigation of the biotransformation pathway of progesterone allowed the putative structural characterization of its main fungal metabolite by GC–MS analysis. The oxidative potential of P. citrinum H7 was selective for the C-17 position of the steroidal nucleus.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectGC–MS
dc.subjectElectrospinning
dc.subjectEndophytic fungus
dc.subjectFungal immobilization
dc.titleBiotransformation of progesterone by endophytic fungal cells immobilized on electrospun nanofibrous membrane.
dc.typeArtigo de periódico
dc.format.extent2407 - 414
riaa.ainfo.id1166133
riaa.ainfo.lastupdate2024-07-31
dc.identifier.doihttps://doi.org/10.1007/s12223-023-01113-4
dc.contributor.institutionFEDERAL UNIVERSITY OF BAHIA
dc.contributor.institutionRAFAELA DA SILVEIRA ANDRE, UNIVERSIDADE FEDERAL DE SÃO CARLOSeng
dc.contributor.institutionFEDERAL UNIVERSITY OF BAHIAeng
dc.contributor.institutionFEDERAL UNIVERSITY OF BAHIAeng
dc.contributor.institutionDANIEL SOUZA CORREA, CNPDIAeng
dc.contributor.institutionFEDERAL UNIVERSITY OF BAHIA.eng
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