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dc.contributor.authorROSSI, P. F.
dc.contributor.authorSANTOS, F. V. dos
dc.contributor.authorALVES, A. L. M. M.
dc.contributor.authorSEMENSATO, L. H.
dc.contributor.authorOLIVEIRA, L. F. R.
dc.contributor.authorSANTOS, D. M. dos
dc.contributor.authorBIANCHI, T. P.
dc.contributor.authorINADA, N. M.
dc.contributor.authorCAMPANA-FILHO, S. P.
dc.contributor.authorORÉFICE, R. L.
dc.contributor.authorCORREA, D. S.
dc.date.accessioned2024-12-28T17:49:57Z-
dc.date.available2024-12-28T17:49:57Z-
dc.date.created2024-12-12
dc.date.issued2024
dc.identifier.citationACS Applied Nano Materials, v. 7, 2024.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1170618-
dc.descriptionTraditional wound dressings have limitations in terms of their antibacterial and anti-inflammatory properties, as well as their ability to maintain a moist wound environment. Addressing these deficiencies with innovative biomaterials, such as hydrogels combined with nanomaterials, can accelerate healing and perform a variety of functions in advanced biomedical materials. In this study, 3D-printed hydrogel membranes were designed and combined with nanofibrous PLA mats produced by the solution blow spinning technique (SBS) for use as a bilayered wound dressing. These membranes were manufactured from gelatin modified with methacrylamide groups (GMA), incorporated with bioactive lignin carbon dots (CDs), and cross-linked using ultraviolet (UV) light. The GMA membranes with the addition of lignin CDs showed antimicrobial activity against Staphylococcus aureus and Escherichia coli and greater mechanical deformation when combined with the PLA fibrous mats, in addition to not causing cytotoxic effects in human fibroblasts. Furthermore, the developed material was capable of maintaining a persistent hydrated environment in the wound area with adequate degradation capacity. Our results demonstrate the potential for manufacturing multifunctional wound dressings utilizing biodegradable and sustainable nanomaterials that are both cost-effective and straightforward to produce, with applications in biomedical fields, including the treatment of skin wound infections.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectLignin carbon dots
dc.subject3D printing
dc.subjectSolution blow spinning
dc.subjectWound dressings
dc.subjectMethacrylated gelatin
dc.title3D-Printed Methacrylated Gelatin−Lignin Carbon Dot Hydrogel Combined with PLA Nanofibers for Wound Dressings.
dc.typeArtigo de periódico
dc.format.extent223519−23531
riaa.ainfo.id1170618
riaa.ainfo.lastupdate2024-12-13
dc.identifier.doibiopolymers,
dc.contributor.institutionFEDERAL UNIVERSITY OF MINAS GERAIS
dc.contributor.institutionUNIVERSITY OF SAO PAULOeng
dc.contributor.institutionFEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR)eng
dc.contributor.institutionUNIVERSITY OF SAO PAULOeng
dc.contributor.institutionLUÍS FERNANDO ROCHA OLIVEIRA, UNIVERSIDADE FEDERAL DE SÃO CARLOSeng
dc.contributor.institutionFRANCISCO VIEIRA DOS SANTOS, UNIVERSIDADE FEDERAL DO PIAUÍeng
dc.contributor.institutionUNIVERSITY OF SAO PAULOeng
dc.contributor.institutionUNIVERSITY OF SAO PAULOeng
dc.contributor.institutionUNIVERSITY OF SAO PAULOeng
dc.contributor.institutionFEDERAL UNIVERSITY OF MINAS GERAISeng
dc.contributor.institutionDANIEL SOUZA CORREA, CNPDIA.eng
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