Título:	Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023.
Autoria:	RESENDE, P. C. JUNQUEIRA, D. M. TOCHETTO, C. OGRZEWALSKA, M. MOTTA, F. C. LOPES, J. APPOLINARIO, L. MACEDO, L. CAETANO, B. MATOS, A. SILVA, T. PEREIRA, E. C. LIMA, L. F. RIEDIGER, I. DEBUR, M. do C. BECKER, G. N. ANDRADE, A. NASR, A. M. L. F. PILER, R. A. VECCHIA, A. C. D. ALMEIDA, W. BROWN, D. SCHAEFER, R. SIQUEIRA, M. M.
Afiliação:	PAOLA CRISTINA RESENDE; DENNIS M. JUNQUEIRA; CAROLINE TOCHETTO; MARIA OGRZEWALSKA; FERNANDO C. MOTTA; JONATHAN LOPES; LUCIANA APPOLINARIO; LARISSA MACEDO; BRAULIA CAETANO; ALINE MATOS; THAUANE SILVA; ELISA CAVALCANTE PEREIRA; LETICIA FERREIRA LIMA; IRINA RIEDIGER; MARIA DO CARMO DEBUR; GUILHERME NARDI BECKER; ALINE ANDRADE; ACÁCIA MARIA LOURENÇO FRANCISCO NASR; ROSANA APARECIDA PILER; ANA CAROLINA DALLA VECCHIA; WALQUÍRIA ALMEIDA; DAVID BROWN; REJANE SCHAEFER, CNPSA; MARILDA M. SIQUEIRA.
Ano de publicação:	2024
Referência:	Nature Communications, v. 15, n. 1, p. 2041-1723, 2024.
Conteúdo:	Abstract: Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020–2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment.
Thesagro:	Suíno Epidemiologia
NAL Thesaurus:	Epidemiology Influenza A virus
Palavras-chave:	Infecções zoonóticas Influenza A Phylogenetics Viral infection Filogenética Infecção viral Zoonotic infections
Digital Object Identifier:	https://doi.org/10.1038/s41467-024-53815-z
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPSA)