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dc.contributor.authorROSSI, P. F.
dc.contributor.authorSANTOS, D. M. dos
dc.contributor.authorMARAGON, C. A.
dc.contributor.authorTEODORO, K. B. R.
dc.contributor.authorCOSTA. C. S.
dc.contributor.authorINADA, N. M.
dc.contributor.authorCORREA, D. S.
dc.contributor.authorORÉFICE, R. L.
dc.date.accessioned2025-05-05T19:47:34Z-
dc.date.available2025-05-05T19:47:34Z-
dc.date.created2025-05-05
dc.date.issued2025
dc.identifier.citationMaterials Today Communications, v. 42, 111418, 2025.
dc.identifier.issn2352-4928eng
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1175299-
dc.descriptionTraditional wound dressings have limitations in terms of their antibacterial and anti-infammatory properties, as well as their ability to maintain a moist wound environment. Addressing these shortcomings in conventional medical materials is essential for advancing wound healing in clinical applications. Additionally, biodegradable polymeric wound dressings have gained signifcant attention as a promising solution to reduce the environmental impact associated with the disposal of wound dressings. In this study, we developed a nanoengineered wound dressing fabricated by solution blow spinning technique by using poly(lactic acid) (PLA) fibrous mats that integrate lignin-derived carbon dots (LCDots), further enhanced with curcumin. This unique combination leverages the antimicrobial and antioxidant properties of curcumin alongside the electrical and photoluminescent features of LCDots, creating a multifunctional dressing with enhanced wound-healing capabilities. The bioactive compounds lignin carbon dots and curcumin were incorporated into the wound dressing to provide antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. Besides, in vitro experiments have demonstrated the superior biocompatibility of these wound dressing platforms towards neonatal human dermal fibroblast cell lines (HDFn). Furthermore, these fibrous mats did not exhibit contact and adhesion of microorganisms according to the microbial penetration test. Additionally, the composite fibrous membrane exhibited favorable hydrophilic properties and mechanical strength, making it a promising candidate for multifunctional wound dressings. Finally, it can be combined with regenerative therapies to exploit their photoluminescent and electrical properties as a stimulus for wound healing.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectSolution blow spinning
dc.subjectLignin carbon dots
dc.subjectAntibacterial activity
dc.subjectWound dressings
dc.subjectBiomaterial
dc.subjectElectrical impedance
dc.titleBiobased composite fibrous membrane using PLA and lignin carbon dots Fabricated via solution blow spinning for wound dressing application.
dc.typeArtigo de periódico
dc.subject.nalthesaurusCurcumin
dc.format.extent212 p.eng
riaa.ainfo.id1175299
riaa.ainfo.lastupdate2025-05-05
dc.identifier.doihttps://doi.org/10.1016/j.mtcomm.2024.111418eng
dc.contributor.institutionPATRÍCIA F. ROSSI, FEDERAL UNIVERSITY OF MINAS GERAIS (UFMG); DANILO M. DOS SANTOS, UNIVERSIDADE DE SÃO PAULO; CRISIANE A. MARANGON, UNIVERSIDADE DE SÃO PAULO; KELCILENE BRUNA TEODORO COSTA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; CAMILA S. COSTA, UNIVERSITY OF SAO PAULO (USP); NATALIA M. INADA, UNIVERSITY OF SAO PAULO (USP); DANIEL SOUZA CORREA, CNPDIA; RODRIGO L. ORÉFICE, FEDERAL UNIVERSITY OF MINAS GERAIS (UFMG).
Aparece en las colecciones:Artigo em periódico indexado (CNPDIA)

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