Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1175378
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dc.contributor.authorBERNARDI, B.
dc.contributor.authorMALAFATTI, J. O. D.
dc.contributor.authorMOREIRA, A. J.
dc.contributor.authorNASCIMENTO, A. C. A.
dc.contributor.authorLIMA, J. B.
dc.contributor.authorVERMEERSCH, L. A. F.
dc.contributor.authorPARIS, E. C.
dc.date.accessioned2025-05-07T20:47:48Z-
dc.date.available2025-05-07T20:47:48Z-
dc.date.created2025-05-07
dc.date.issued2025
dc.identifier.citationDiscover Nano, v. 20, 8, 2025.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1175378-
dc.descriptionMultifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric bers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 ± 8 m2 g−1 ), high crystallinity and particles with a diameter of up to 100 nm were produced under optimized synthesis conditions (100 °C/4 h). Zeolites were incorporated into polymeric nanobers to be a cloxacillin (CLX) carrier in wound treatment, using electrospinning as an ecient synthesis method. The bers produced showed good mechanical resistance and the ncorporation of CLX was proven by assays to inhibit the growth of Staphylococcus aureus bacteria. The controlled release of CLX in dierent pH conditions, which simulate the wound environment, was carried out for up to 229 h, achieving a released CLX concentration of up to 6.18 ± 0.02 mg L−1 . These results prove that obtaining a hybrid fiber (polymer-zeolite) to incorporate drugs to be released in a controlled manner was successfully achieved. The bactericidal activity of this material shows that its use for measured applications could be an alternative to conventional methods.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectAntimicrobial
dc.subjectElectrospun
dc.subjectFaujasite
dc.subjectPolycaprolactone
dc.titleAntimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin‑controlled release.
dc.typeArtigo de periódico
dc.format.extent215 p.
riaa.ainfo.id1175378
riaa.ainfo.lastupdate2025-05-07
dc.identifier.doihttps://doi.org/10.1186/s11671-024-04161-y
dc.contributor.institutionFEDERAL UNIVERSITY OF SÃO CARLOS; SÃO PAULO STATE UNIVERSITY (UNESP); FEDERAL UNIVERSITY OF SÃO CARLOS; SÃO PAULO STATE UNIVERSITY (UNESP); ELAINE CRISTINA PARIS, CNPDIA.
Appears in Collections:Artigo em periódico indexado (CNPDIA)

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