Title:	Chemical composition and antidiabetic potential of a phenolic-rich extract from cashew fiber.
Authors:	XAVIER FILHO, R. R. B. RIBEIRO, P. R. V. SILVA, L. M. A. e PEREIRA, L. L. FREIRE, G. A. MARTINS, C. B. R. WONG, D. V. T. DIONISIO, A. P. ALENCAR, N. M. N. de FREDERICO, M. J. S. CANUTO, K. M.
Affiliation:	RAIMUNDO RIGOBERTO BARBOSA XAVIER FILHO, UNIVERSIDADE ESTADUAL DO CEARÁ PAULO RICELI VASCONCELOS RIBEIRO, CNPAT LORENA MARA ALEXANDRE E SILVA, CNPAT LANDERSON LOPES PEREIRA, UNIVERSIDADE FEDERAL DO CEARÁ GABRIELA ARAÚJO FREIRE, UNIVERSIDADE FEDERAL DO CEARÁ CAIO BRUNO RODRIGUES MARTINS, UNIVERSIDADE FEDERAL DO CEARÁ DEYSI VIVIANA TENAZOA WONG, UNIVERSIDADE FEDERAL DO CEARÁ ANA PAULA DIONISIO, CNPAT NYLANE MARIA NUNES DE ALENCAR, UNIVERSIDADE FEDERAL DO CEARÁ MARISA JADNA SILVA FREDERICO, UNIVERSIDADE FEDERAL DO CEARÁ KIRLEY MARQUES CANUTO, CNPAT.
Date Issued:	2025
Citation:	ACS Food Science & Technology, v. 5, n. 4, p. 1687–1698, Apr. 2025.
Description:	Cashew fiber is a byproduct used as an ingredient in food products; however, little is known about its functional properties. Therefore, we evaluated the chemical composition and antidiabetic potential of a phenolic-rich extract from the cashew fiber (PECF) using spectrometric techniques and experiments with C57BL/6 mice to assess its effect on glycemia and insulin resistance. In the glucose tolerance test, fasted animals received PECF (1−100 mg/kg i.p.) followed by a glucose load of 2 g/kg. Dexamethasone was used to induce insulin resistance, and the animals received PECF daily for 5 days. As a result, PECF (1 mg/kg) reduced blood glucose, triglycerides, and total cholesterol levels; meanwhile, HDL levels and insulin sensitivity were increased. Its mechanism of action seems to be related to α-glucosidase inhibitory and antioxidant activities of phenolic acids and flavonol glycosides by increasing glutathione and reducing TBARs. Thus, cashew fiber was shown to be a good source of hypoglycemic compounds for plant-based foods and nutraceuticals potentially useful for diabetes control.
Thesagro:	Caju Anacardium Occidentale Composto Fenólico Flavonóide Antioxidante Diabete
NAL Thesaurus:	Phenolic compounds Flavonoids Phenolic acids Dietary fiber Diabetes mellitus Insulin resistance Glycemic control Glucose tolerance Oxidative stress
Keywords:	Fibra de caju Cashew fiber Extrato rico em compostos fenólicos Phenolic-rich extract Atividade antidiabética Antidiabetic activity Atividade hipoglicemiante Hypoglycemic activity Inibição da alfa-glucosidase Alpha-glucosidase inhibition Ácido anacárdico Anacardic acid Glicosídeos de flavonol Flavonol glycosides GLUT-4
ISSN:	2692-1944
DOI:	https://doi.org/10.1021/acsfoodscitech.5c00074
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPAT)