Title:	Microwave-assisted catalytic transfer hydrogenation of chalcones: a green, fast, and efficient one-step reduction using ammonium formate and Pd/C.
Authors:	SILVA, W. A. SILVA, S. C. S. T. da NOGUEIRA, F. M. ALMEIDA, L. A. R.
Affiliation:	WENDER ALVES SILVA, UNIVERSITY OF BRASILIA (IQ-UNB); SAYURI CRISTINA SANTOS TAKADA DA SILVA, CENARGEN; FELIPE MARQUES NOGUEIRA, UNIVERSITY OF BRASILIA (IQ-UNB); LUIZ ARTHUR RAMOS ALMEIDA, UNIVERSITY OF BRASILIA (IQ-UNB).
Date Issued:	2025
Citation:	Organics, v. 6, n. 3, 40, 2025.
Description:	Catalytic transfer hydrogenation (CTH) and microwave-assisted organic synthesis (MAOS) have each advanced the sustainability of reduction chemistry; however, their combined application to conjugated enones remains largely unexplored. To the best of our knowledge, no unified protocol has been reported for the rapid, one-pot conversion of chalcones into saturated alcohols under microwave irradiation. Herein, we report a concise and green method that integrates MAOS with Pd/C-catalyzed CTH, employing inexpensive ammonium formate in ethanol. In contrast to state-of-the-art hydrogenations that require pressurized H2 or costly metal complexes, our strategy (i) achieves complete conversion within 20 min at 60 °C, (ii) tolerates both electron-rich and electron-poor substrates, (iii) reduces nitro-substituted chalcones in a single step, and (iv) consumes < 0.005 kWh per reaction—an approximately 250-fold energy saving relative to conventional procedures. These results position microwave-driven CTH as a scalable alternative for synthesizing pharmacologically relevant saturated alcohol scaffolds from readily available chalcones.
NAL Thesaurus:	Chalcones Green chemistry
Keywords:	Microwave-assisted synthesis Catalytic transfer hydrogenation Energy-efficient synthesis
Notes:	Na publicação: Sayuri Cristina Santos Takada.
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CENARGEN)