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dc.contributor.authorSILVA, W. A.
dc.contributor.authorSILVA, S. C. S. T. da
dc.contributor.authorGATTO, C. C.
dc.contributor.authorMARAVALHO, I. V.
dc.date.accessioned2026-01-26T13:48:36Z-
dc.date.available2026-01-26T13:48:36Z-
dc.date.created2026-01-26
dc.date.issued2026
dc.identifier.citationCatalysts, v. 16, 96, 2026.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1183849-
dc.description1,4-Dihydropyridines (1,4-DHPs) are privileged heterocycles with broad relevance in medicinal chemistry and redox-related applications. However, conventional Hantzsch syntheses typically require prolonged thermal heating and often suffer from limited efficiency and regioselectivity. Herein, we report a sustainable and efficient microwave-assisted protocol for the synthesis of 1,4-DHPs, employing phosphotungstic acid (HPW) as a heteropolyacid catalyst in PEG-400 as a green reaction medium. The multicomponent cyclocondensation proceeds rapidly under microwave irradiation, affording the desired 1,4-DHP derivatives in good to excellent yields within short reaction times. Compared with classical acid-catalyzed conditions, the HPW/PEG-400 system markedly enhances regioselectivity toward the 1,4-DHP framework while simultaneously reducing energy input. Moreover, the catalytic system exhibits good recyclability, underscoring its potential as a practical and environmentally responsible platform for the synthesis of bioactive 1,4-dihydropyridine scaffolds.
dc.language.isoeng
dc.rightsopenAccess
dc.subject1 4-dihydropyridines
dc.subjectMulticomponent reaction
dc.subjectHeteropolyacid catalyst
dc.subjectPEG-400
dc.subjectMicrowave-assisted organic synthesis
dc.titleMicrowave-assisted synthesis of 1,4-Dihydropyridines via the Hantzsch reaction using a recyclable HPW/PEG-400 catalytic system.
dc.typeArtigo de periódico
dc.subject.nalthesaurusPhosphotungstic acid
dc.description.notesNa publicação: Sayuri Cristina Santos Takada.
riaa.ainfo.id1183849
riaa.ainfo.lastupdate2026-01-26
dc.identifier.doihttps://doi.org/10.3390/catal16010096
dc.contributor.institutionWENDER ALVES SILVA, UNIVERSITY OF BRASILIA; SAYURI CRISTINA SANTOS TAKADA DA SILVA, CENARGEN; CLAUDIA CRISTINA GATTO, UNIVERSITY OF BRASILIA; IZABELLA VITORIA MARAVALHO, UNIVERSITY OF BRASILIA.
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