Title:	Microwave-assisted synthesis of 1,4-Dihydropyridines via the Hantzsch reaction using a recyclable HPW/PEG-400 catalytic system.
Authors:	SILVA, W. A. SILVA, S. C. S. T. da GATTO, C. C. MARAVALHO, I. V.
Affiliation:	WENDER ALVES SILVA, UNIVERSITY OF BRASILIA; SAYURI CRISTINA SANTOS TAKADA DA SILVA, CENARGEN; CLAUDIA CRISTINA GATTO, UNIVERSITY OF BRASILIA; IZABELLA VITORIA MARAVALHO, UNIVERSITY OF BRASILIA.
Date Issued:	2026
Citation:	Catalysts, v. 16, 96, 2026.
Description:	1,4-Dihydropyridines (1,4-DHPs) are privileged heterocycles with broad relevance in medicinal chemistry and redox-related applications. However, conventional Hantzsch syntheses typically require prolonged thermal heating and often suffer from limited efficiency and regioselectivity. Herein, we report a sustainable and efficient microwave-assisted protocol for the synthesis of 1,4-DHPs, employing phosphotungstic acid (HPW) as a heteropolyacid catalyst in PEG-400 as a green reaction medium. The multicomponent cyclocondensation proceeds rapidly under microwave irradiation, affording the desired 1,4-DHP derivatives in good to excellent yields within short reaction times. Compared with classical acid-catalyzed conditions, the HPW/PEG-400 system markedly enhances regioselectivity toward the 1,4-DHP framework while simultaneously reducing energy input. Moreover, the catalytic system exhibits good recyclability, underscoring its potential as a practical and environmentally responsible platform for the synthesis of bioactive 1,4-dihydropyridine scaffolds.
NAL Thesaurus:	Phosphotungstic acid
Keywords:	1 4-dihydropyridines Multicomponent reaction Heteropolyacid catalyst PEG-400 Microwave-assisted organic synthesis
DOI:	https://doi.org/10.3390/catal16010096
Notes:	Na publicação: Sayuri Cristina Santos Takada.
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CENARGEN)