Title:	Lactic acid bacteria isolated from mammalian feces exhibit distinct diversity and probiotic traits.
Authors:	FIGUEIREDO, M. I. da S. MELLO, I. S. BUENO, L. de G. MENDES, R. R. W. ALMEIDA, J. M. dos S. ERIKSSON, A. SILVA, G. F. da SOARES, M. A.
Affiliation:	MARIA ISABELA DA SILVA FIGUEIREDO, UNIVERSIDADE FEDERAL DE MATO GROSSO; IVANI SOUZA MELLO, UNIVERSIDADE FEDERAL DE MATO GROSSO; LUANA DE GUIMARÃES BUENO, UNIVERSIDADE FEDERAL DE MATO GROSSO; RISYA REGINA WESTPHAL MENDES, UNIVERSIDADE FEDERAL DE MATO GROSSO; JONATHAN MÁDSON DOS SANTOS ALMEIDA, UNIVERSIDADE FEDERAL DE MATO GROSSO; ALAN ERIKSSON, UNIVERSIDADE FEDERAL DE MATO GROSSO; GILVAN FERREIRA DA SILVA, CPAA; MARCOS ANTÔNIO SOARES, UNIVERSIDADE FEDERAL DE MATO GROSSO.
Date Issued:	2026
Citation:	World Journal of Microbiology and Biotechnology, v. 42, art. 128, 2026.
Description:	Lactic acid bacteria (LAB) play an essential role in mammalian gut health and are promising candidates for probiotic use. In this study, we have identified LAB isolated from fecal samples of bats, calves, cats, or piglets or from the vaginal mucosa or teat skin of a lactating sow. Specifically, we identified 98 lineages belonging to the phyla Bacillota, Pseudo-monadota, or Actinomycetota. Enterococcus faecalis was the only species common to all mammal groups. The LAB communities were functionally different depending on the host they originated from. Caenorhabditis elegans fed with Lactiplantibacillus plantarum PA27 lived 42.9% longer than C. elegans fed with Escherichia coli OP50. Additionally, C. elegans worms fed with L. plantarum PA17 or PA19 had longer body length than C. elegans worms fed with E. coli OP50. L. plantarum PA17, PA19, and PA27, isolated from piglets, were selected to evaluate how the signaling pathway (DAF-16/FOXO) was modulated during regulation of oxidative and thermal stress-related genes (sod-3, hsp-16.2, and gcs-1). The proportion of C. elegans with nuclear DAF-16 increased among worms fed with L. plantarum PA17, PA19, or PA27 (40% to 96%) compared to worms fed with the E. coli OP50 control (22%). The sod-3 and gcs-1 genes were more expressed in C. elegans fed with L. plantarum PA27. These results highlight that LAB isolated from mammals are potentially effective probiotics that can modulate responses to oxidative stress by activating the DAF-16/FOXO pathway, which promotes gut health and longevity.
NAL Thesaurus:	Caenorhabditis elegans Longevity
Keywords:	Functional traits Gut microbiota Host-micromicrobe interaction
DOI:	https://doi.org/10.1007/s11274-026-04801-8
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPAA)