Title:	Salinirifamycins A−E: Rifamycin S Derivatives from the Brazilian Marine Actinomycete Salinispora arenicola.
Authors:	SILVA, A. B. da PINTO, F. C. L. SILVEIRA, E. R. PAULO, T. de F. WILKE, D. V. FERREIRA, E. G. COSTA-LOTUFO CANUTO, K. M. MARINHO FILHO, J. D. B. BARROS, A. B. NUZZO, G. FONTANA, A. MONTEIRO, R. K. V.
Affiliation:	ALISON BATISTA DA SILVA, UNIVERSIDADE FEDERAL DO CEARÁ FRANCISCO CHAGAS L. PINTO, UNIVERSIDADE FEDERAL DO CEARÁ EDILBERTO R. SILVEIRA, UNIVERSIDADE FEDERAL DO CEARÁ TERCIO DE FREITAS PAULO, UNIVERSIDADE FEDERAL DO CEARÁ DIEGO V. WILKE, UNIVERSIDADE FEDERAL DO CEARÁ ELTHON G. FERREIRA, UNIVERSIDADE FEDERAL DO CEARÁ LETICIA V. COSTA-LOTUFO, UNIVERSIDADE DE SÃO PAULO KIRLEY MARQUES CANUTO, CNPAT JOSÉ DELANO BARRETO MARINHO-FILHO, UNIVERSIDADE FEDERAL DO DELTA DO PARNAÍBA AYSLAN B. BARROS, UNIVERSIDADE FEDERAL DO DELTA DO PARNAÍBA GENOVEFFA NUZZO, ISTITUTO DI CHIMICA BIOMOLECOLARE, BIO-ORGANIC CHEMISTRY UNIT ANGELO FONTANA, ISTITUTO DI CHIMICA BIOMOLECOLARE, BIO-ORGANIC CHEMISTRY UNIT NORBERTO KÁSSIO V. MONTEIRO, UNIVERSIDADE FEDERAL DO CEARÁ.
Date Issued:	2026
Citation:	Journal of Natural Products, 89, 304−312, 2026.
Description:	Five new rifamycin derivatives, named salinirifamy- cins A−E (1−5), were isolated from a Brazilian marine Salinispora arenicola (BRA-213) strain extract. The structures of the new rifamycins were elucidated using a combination of NMR, IR, UV, and MS spectroscopic techniques, quantum-chemical calculations (DFT-calculated 13 C NMR chemical shifts and DP4+ probability analysis), and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1, 2, and 4 displayed antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with MIC values ranging from 2.0 to 125.0 μg/ mL, whereas 5 exhibited an MIC of 0.02 μg/mL to S. aureus, similar to the positive control rifampicin (MIC 0.03 μg/mL).
NAL Thesaurus:	Actinobacteria
Keywords:	Salinirifamicinas Salinispora arenicola
DOI:	https://doi.org/10.1021/acs.jnatprod.5c01381
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPAT)