Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1187380
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorCOATRINI-SOARES, A.
dc.contributor.authorSOARES, J. C.
dc.contributor.authorPOPOLIN-NETO, M.
dc.contributor.authorSOARES, G. O. N.
dc.contributor.authorMELLO, S. S. de
dc.contributor.authorSANCHES, E. A.
dc.contributor.authorPAULOVICH, F. V.
dc.contributor.authorMATTOSO, L. H. C.
dc.date.accessioned2026-06-08T19:56:51Z-
dc.date.available2026-06-08T19:56:51Z-
dc.date.created2026-06-08
dc.date.issued2026
dc.identifier.citationACS Applied Nano Materials, v. 9, 2026,
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1187380-
dc.descriptionAvianinfluenzaviruses,particularlytheH5N1subtype,representa majorglobal threatduetotheirhightransmissibilityandmortalityrates.Rapid, low-cost, andreliabledetection is essential for controllingviral spread inboth avian and human populations. This work presents amicrofluidic electronic tongue composed of interdigitated electrodes functionalized with one-layer, nanostructuredfilms fromrenewable sources zein, jacalin, concanavalinA, and sericin-modifiedgoldnanoparticles(AuNP-SER)forthedetectionofanti-H5N1 antibodies. Electrical impedance spectroscopywas employed tomonitor the interactionbetweenantibodiesandmoleculararchitectures,supportedbycontact angle and polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS)analyses toelucidatethedetectionmechanism.Thesensorsexhibitedhighsensitivityandselectivity,withlimitsof detectionrangingfrom0.42to0.56ng/mLandnofalsepositiveswhentestedagainstcommonaviandiseaseantibodies.Information visualizationtechniquesdemonstratedstrongdiscriminationamonganalytes,withsilhouettecoefficientsupto0.81fortheelectronic tongue.Usingthemultidimensionalcalibrationspace(MCS)approachwithdecision-treemodels,thesystemachieved78%accuracy inmulticlassclassificationof10antibodyconcentrationsand98.6%accuracyindistinguishingpositivefromnegativesamples.The MCSrevealedthat the2154Hz frequencyfromtheAuNP-SERunitwas influential inbothscenarios.Theseresultsconfirmthe potential of theelectronic tongueproposedasa robust, interpretable, and low-costdiagnostic tool forH5N1-relateddiseases in veterinaryandclinical contexts.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectImpedance spectroscopy
dc.subjectH5N1
dc.subjectMachine learning
dc.titleMicrofluidic Electronic Tongue Made with Nanostructured Films of Proteins from Renewable Sources to Detect H5N1 Antibodiesfrom Avian Influenza Virus.
dc.typeArtigo de periódico
dc.format.extent26581−6590
riaa.ainfo.id1187380
riaa.ainfo.lastupdate2026-06-08
dc.identifier.doihttps://doi.org/10.1021/acsanm.6c00138 A
dc.contributor.institutionFEDERAL UNIVERSITY OF AMAZONAS, 69067-005 MANAUS, AMAZONAS
dc.contributor.institutionUNIVERSITY OF SÃO PAULO (USP)eng
dc.contributor.institutionFEDERAL INSTITUTE OF SÃO PAULO (IFSP), 14804-296 ARARAQUARA, SÃO PAULO, BRAZILeng
dc.contributor.institutionUNIVERSITY OF SÃO PAULO (USP)eng
dc.contributor.institutionHARVARD MEDICAL SCHOOL, BOSTON, MASSACHUSETTS MA02114, UNITED STATESeng
dc.contributor.institutionFEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR), 13565-905 SÃO CARLOS, SÃO PAULO, BRAZILeng
dc.contributor.institutionEINDHOVEN UNIVERSITY OF TECHNOLOGY (TU/E), 5600 MB EINDHOVEN, THE NETHERLANDSeng
dc.contributor.institutionLUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA.eng
Aparece nas coleções:Artigo em periódico indexado (CNPDIA)

Arquivos associados a este item:
Arquivo TamanhoFormato 
microfluidic-electronic-tongue-made-with-nanostructured-films-of-proteins-from-renewable-sources-to-detect-h5n1.pdf4,76 MBAdobe PDFVisualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas

FacebookTwitterDeliciousLinkedInGoogle BookmarksMySpace