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dc.contributor.authorPRÍNCIPE, L. de A.
dc.contributor.authorMARCHI, P. H.
dc.contributor.authorMICHELETTI, C. D.
dc.contributor.authorVALIM, J. M. B. de C.
dc.contributor.authorCÔNSOLO, N. R. B.
dc.contributor.authorPEDREIRA, R. S.
dc.contributor.authorJEREMIAS, J. T.
dc.contributor.authorRIBEIRO, G. H.
dc.contributor.authorCOLNAGO, L. A.
dc.contributor.authorBALIEIRO, J. C. de C.
dc.contributor.authorVENDRAMINI, T. H. A.
dc.date.accessioned2026-07-03T18:53:32Z-
dc.date.available2026-07-03T18:53:32Z-
dc.date.created2026-07-03
dc.date.issued2026
dc.identifier.citationJournal of Veterinary Internal Medicine, v. 40, n. 1, aalaf075, 2026.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1188002-
dc.descriptionAbstract Background: Obesity in cats is a complex metabolic condition, and understanding its metabolic processes is e ssential for gaining new insights into nutrition. Hypothesis/Objectives: Investigate the effects of enzymatically-hydrolyzed poultry byproduct meal (EHPM-c) on the serum metabolomic p rofile of obese cats. Animals: Eighteen adult, neutered, obese domestic cats were enrolled in the study. All subjects underwent comprehensive veterinary evaluations to confirm overall health and rule o ut concurrent systemic diseases, ensuring a homogenous study population. Methods:Cats were randomized into 2 groups and fed for 45 days with isonutritive diets containing either 30.8% conventional poultry byproduct meal (CPM-c) with 0.0% EHPM-c, or 17.0% CPM-c with 12.0% EHPM-c. After a 30-day diet standardization period, evaluationswereperformedatbaseline(T0)and45days(T45)afterconsumptionoftheexperimentaldiets.Metabolic spectra wereobtained using nuclearmagnetic resonance spectroscopy and analyzed using MetaboAnalyst®. Results: Principal component analysis did not identify differences in the overall metabolite profiles between the groups, but discriminant analysis identified changes in the intensities of valine, acetate, 1-methylhistidine, and glycerol in the test group after 45 days. Additionally, pathway analysis indicated a significant effect on propanoate metabolism, ethanol degradation, fatty acid biosynthesis, and glycerolipid metabolism in the test group. Conclusions and clinical importance: These findings suggest enhanced fat mobilization and improved utilization of branched chain amino acids, potentially benefiting ener gy metabolism in obese cats.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectNuclearmagnetic resonance spectroscopy
dc.subjectComplex metabolic condition
dc.titleSerum metabolomics identifies metabolic changes in obese cats fed enzymatically hydrolyzed poultry byproduct meal.
dc.typeArtigo de periódico
dc.format.extent214 p.
riaa.ainfo.id1188002
riaa.ainfo.lastupdate2026-07-03
dc.identifier.doihttps://doi.org/10.1093/jvimsj/aalaf075
dc.contributor.institutionUNIVERSITY OF SAO PAULO; UNIVERSITY OF SAO PAULO; UNIVERSITY OF SAO PAULO; UNIVERSITY OF SÃO PAULO; UNIVERSITY OF SÃO PAULO; GRANDFOOD INDUSTRIA E COMERCIO LTDA; GRANDFOOD INDUSTRIA E COMERCIO LTDA; LUIZ ALBERTO COLNAGO, CNPDIA; UNIVERSITY OF SAO PAULO; UNIVERSITY OF SAO PAULO.
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