Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1188121
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dc.contributor.authorMOREIRA, J. B. S.
dc.contributor.authorRIBEIRO, R. V. R.
dc.contributor.authorCÔNSOLO, N. R. B.
dc.contributor.authorRIBEIRO G. H.
dc.contributor.authorCOLNAGO, L. A.
dc.contributor.authorTORRES, R. N. S.
dc.contributor.authorMACHADO NETO, O. R.
dc.contributor.authorCURI, R. A.
dc.contributor.authorCHARDULO, L. A. L.
dc.contributor.authorBALDASSINI, W. A.
dc.date.accessioned2026-07-08T14:49:16Z-
dc.date.available2026-07-08T14:49:16Z-
dc.date.created2026-07-08
dc.date.issued2026
dc.identifier.citationACS Omega, v. 10, 2025.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1188121-
dc.descriptionThis study aimed to identify andquantify serum metabolites inbeef cattleexhibitingdifferent growthratesduring the finishing phase. A total of 120Nellore (Bos indicus) bulls, averaging387±14kginbodyweightand24±2monthsofage, wereevaluated.Theanimalswerehousedfor115days,andonday 21(endof thefirstadaptationstep),bloodsampleswerecollected fromthecoccygealveinformetabolomicanalysis.Basedonaverage daily gain (ADG), two contrasting groups were selected: high performance (HP; n=12) and lowperformance (LP; n=12). Serumsamples collected on day 21were analyzed by proton nuclearmagnetic resonance (1HNMR) toextract andquantify metabolites. Longissimusmuscle area (LMA), backfat thickness (BFT), and hot carcass weight (HCW) were measured via ultrasound at the end of the finishing period. Animal performancewas affected by growth rate, withHP animals showing significantlygreater final bodyweight,HCW, andBFT(p<0.05). Atotal of 47 serummetaboliteswere identified, including essential andnonessential aminoacids, sugars, peptides, vitamins, aminoacidderivatives, andorganicacids.HPcattleexhibited higherconcentrationsofthreonine,glycolate,ornithine,histidine,andcreatinine(p<0.05),whileLPanimalsshowedgreaterlevels of phenylalanine, succinate, acetate, asparagine, and 2-hydroxyisobutyrate (p < 0.05). Key enriched pathways included the mitochondrialelectrontransportchain(p=0.06),ethanoldegradation(p=0.08),andthreonineand2-oxobutanoatedegradation(p =0.09).ThesefindingssuggestenhancedenergymetabolisminHPanimals,drivenbygreatersubstratediversity,whileLPanimals mayexhibit impairedmitochondrial function,negativelyimpactingperformance.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectMetabolomic analysis
dc.subjectSerum metabolites
dc.titleMetabolomic Profiling of Serum Reveals Energy Metabolism Differences in Nellore Bulls with Divergent Growth Rates during Feedlot Finishing.
dc.typeArtigo de periódico
dc.format.extent248272−48281
riaa.ainfo.id1188121
riaa.ainfo.lastupdate2026-07-08
dc.identifier.doihttps://doi.org/10.1021/acsomega.5c05181
dc.contributor.institutionSÃO PAULO STATE UNIVERSITY (UNESP)
dc.contributor.institutionSÃO PAULO STATE UNIVERSITY (UNESP)eng
dc.contributor.institutionUNIVERSITY OF SÃO PAULO (USP)eng
dc.contributor.institutionLUIZ ALBERTO COLNAGO, CNPDIAeng
dc.contributor.institutionSÃO PAULO STATE UNIVERSITY (UNESP)eng
dc.contributor.institutionSÃO PAULO STATE UNIVERSITY (UNESP)eng
dc.contributor.institutionSÃO PAULO STATE UNIVERSITY (UNESP)eng
dc.contributor.institutionSÃO PAULO STATE UNIVERSITY (UNESP)eng
dc.contributor.institutionSÃO PAULO STATE UNIVERSITY (UNESP).eng
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