Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/888216
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dc.contributor.authorSTEIBEL, J. P.pt_BR
dc.contributor.authorBATES, R. O.pt_BR
dc.contributor.authorROSA, G. J. M.pt_BR
dc.contributor.authorTEMPELMAN, R. J.pt_BR
dc.contributor.authorRILINGTON, V. D.pt_BR
dc.contributor.authorRAGAVENDRAN, A.pt_BR
dc.contributor.authorRANEY, NANCY E.pt_BR
dc.contributor.authorRAMOS, A. M.pt_BR
dc.contributor.authorCARDOSO, F. F.pt_BR
dc.contributor.authorEDWARDS, D. B.pt_BR
dc.contributor.authorERNST, C. W.pt_BR
dc.date.accessioned2011-05-10T11:11:11Zpt_BR
dc.date.available2011-05-10T11:11:11Zpt_BR
dc.date.created2011-05-10pt_BR
dc.date.issued2011pt_BR
dc.identifier.citationPLoS ONE, San Francisco, v. 6, n. 2, e16766, Feb. 2011.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/888216pt_BR
dc.descriptionBackground: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants. A powerful strategy for revealing candidate genes involves expression QTL (eQTL) mapping, where the mRNA abundance of a set of transcripts is used as the response variable for a QTL scan. Methodology/Principal Findings: We utilized a whole genome expression microarray and an F2 pig resource population to conduct a global eQTL analysis in loin muscle tissue, and compared results to previously inferred phenotypic QTL (pQTL) from the same experimental cross. We found 62 unique eQTL (FDR ,10%) and identified 3 gene networks enriched with genes subject to genetic control involved in lipid metabolism, DNA replication, and cell cycle regulation. We observed strong evidence of local regulation (40 out of 59 eQTL with known genomic position) and compared these eQTL to pQTL to help identify potential candidate genes. Among the interesting associations, we found aldo-keto reductase 7A2 (AKR7A2) and thioredoxin domain containing 12 (TXNDC12) eQTL that are part of a network associated with lipid metabolism and in turn overlap with pQTL regions for marbling, % intramuscular fat (% fat) and loin muscle area on Sus scrofa (SSC) chromosome 6. Additionally, we report 13 genomic regions with overlapping eQTL and pQTL involving 14 local eQTL. Conclusions/Significance: Results of this analysis provide novel candidate genes for important complex pig phenotypes.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleGenome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2011-08-04T11:11:11Zpt_BR
dc.subject.thesagroSuínopt_BR
dc.subject.thesagroGenéticapt_BR
riaa.ainfo.id888216pt_BR
riaa.ainfo.lastupdate2011-08-04pt_BR
dc.contributor.institutionJUAN PEDRO STEIBEL, Department of Animal Science, Michigan State University; RONALD O. BATES, Department of Animal Science, Michigan State University; GUILHERME J. M. ROSA, Department of Animal Sciences, University of Wisconsin; ROBERT J. TEMPELMAN, Department of Animal Science, Michigan State University; VALENCIA D. RILINGTON, Department of Animal Science, Michigan State University; ASHOK RAGAVENDRAN, Department of Animal Science, Michigan State University; NANCY E. RANEY, Department of Animal Science, Michigan State University; ANTONIO MARCOS RAMOS, Department of Animal Science, Michigan State University; FERNANDO FLORES CARDOSO, CPPSUL; DAVID B. EDWARDS, Department of Animal Science, Michigan State University; ERNST, C. W., Department of Animal Science, Michigan State University.pt_BR
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