Title:	Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
Authors:	FERRAZ, L. F. C. SOARDI, F. FALCÃO, P. NESHICH, G. MELLO, M. P. de
Affiliation:	LUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp.
Date Issued:	2006
Citation:	In: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006.
Pages:	Não paginado.
Description:	Short abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported.
Thesagro:	Biologia molecular
NAL Thesaurus:	Mutation Hyperplasia Molecular Biology
Keywords:	Mutação gênica Hiperplasia adrenal congenital Modelagem molecular
Notes:	ISMB, X-MEETING 2006. Poster D-12.
Type of Material:	Resumo em anais e proceedings
Access:	openAccess
Appears in Collections:	Resumo em anais de congresso (CNPTIA)