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dc.contributor.authorMELO, R. C.pt_BR
dc.contributor.authorRIBEIRO, C.pt_BR
dc.contributor.authorMURRAY, C. S.pt_BR
dc.contributor.authorVELOSO, C. J. M.pt_BR
dc.contributor.authorSILVEIRA, C. H. dapt_BR
dc.contributor.authorNESHICH, G.pt_BR
dc.contributor.authorMEIRA JUNIOR, W.pt_BR
dc.contributor.authorCARCERONI, R. L.pt_BR
dc.contributor.authorSANTORO, M. M.pt_BR
dc.date.accessioned2011-04-10T11:11:11Zpt_BR
dc.date.available2011-04-10T11:11:11Zpt_BR
dc.date.created2007-12-07pt_BR
dc.date.issued2007pt_BR
dc.identifier.citationGenetics and Molecular Research, v. 6, n. 4, p. 946-963, 2007.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/969pt_BR
dc.descriptionWe propose a novel method for defining patterns of contacts present in protein-protein complexes. A new use of the traditional contact maps (more frequently used for representation of the intra-chain contacts) is presented for analysis of inter-chain contacts. Using an algorithm based on image processing techniques, we can compare protein-protein interaction maps and also obtain a dissimilarity score between them. The same algorithm used to compare the maps can align the contacts of all the complexes and be helpful in the determination of a pattern of conserved interactions at the interfaces. We present an example for the application of this method by analyzing the pattern of interaction of bovine pancreatic trypsin inhibitors and trypsins, chymotrypsins, a thrombin, a matriptase, and a kallikrein - all classified as serine proteases. We found 20 contacts conserved in trypsins and chymotrypsins and 3 specific ones are present in all the serine protease complexes studied. The method was able to identify important contacts for the protein family studied and the results are in agreement with the literature.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectBioinformáticapt_BR
dc.subjectInteração proteína-proteínapt_BR
dc.subjectMapas de contatopt_BR
dc.subjectContact mapspt_BR
dc.subjectSerine proteasespt_BR
dc.titleFinding protein-protein interaction patterns by contact map matching.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-05-11T11:11:11Zpt_BR
dc.subject.nalthesaurusBioinformaticspt_BR
dc.subject.nalthesaurusSerine proteinasespt_BR
dc.subject.nalthesaurusprotein-protein interactionspt_BR
riaa.ainfo.id969pt_BR
riaa.ainfo.lastupdate2017-05-11pt_BR
dc.contributor.institutionUFMG; UFMG; UFMG; UFMG; UFMG; GORAN NESHICH, CNPTIA; UFMG; UFMG; UFMG.pt_BR
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