Title:	Genome-wide association study for performance traits in chickens using genotype by sequencing approach.
Authors:	PERTILLE, F. MOREIRA, G. C. M. M. ZANELLA, R. NUNES, J. de R. da S. BOSCHIERO, C. ROVADOSCKI, G. A. MOURÃO, G. B. LEDUR, M. C. COUTINHO, L. L.
Affiliation:	FÁBIO PÉRTILLE, ESALQ; GABRIEL COSTA MONTEIRO MOREIRA, ESALQ; RICARDO ZANELLA, UPF; JOSÉ DE RIBAMAR DA SILVA NUNES, ESALQ; CLARISSA BOSCHIERO, ESALQ; GREGORI ALBERTO ROVADOSCKI, ESALQ; GERSON BARRETO MOURÃO, ESALQ; MONICA CORREA LEDUR, CNPSA; LUIZ LEHMANN COUTINHO, ESALQ.
Date Issued:	2017
Citation:	Scientific Reports, v. 7, n. 41748, 2017.
Description:	Performance traits are economically important and are targets for selection in breeding programs, especially in the poultry industry. To identify regions on the chicken genome associated with performance traits, different genomic approaches have been applied in the last years. The aim of this study was the application of CornellGBS approach (134,528 SNPs generated from a PstI restriction enzyme) on Genome-Wide Association Studies (GWAS) in an outbred F2 chicken population. We have validated 91.7% of these 134,528 SNPs after imputation of missed genotypes. Out of those, 20 SNPs were associated with feed conversion, one was associated with body weight at 35 days of age (P < 7.86E-07) and 93 were suggestively associated with a variety of performance traits (P < 1.57E-05). The majority of these SNPs (86.2%) overlapped with previously mapped QTL for the same performance traits and some of the SNPs also showed novel potential QTL regions. The results obtained in this study suggests future searches for candidate genes and QTL refinements as well as potential use of the SNPs described here in breeding programs.
Thesagro:	Melhoramento genético animal Genoma Galinha
NAL Thesaurus:	Animal breeding Genome Chickens
Keywords:	Ave
DOI:	10.1038/srep41748
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPSA)