Título:	Tag SNP selection for prediction of adaptation traits in Braford and Hereford cattle using Bayesian methods.
Autor:	REIMANN, F. A. CAMPOS, G. S. JUNQUEIRA, V. S. COMIN, H. B. SOLLERO, B. P. CARDOSO, L. L. COSTA, R. F. da BOLIGON, A. A. YOKOO, M. J. I. CARDOSO, F. F.
Afiliación:	FERNANDO A. REIMANN, UNIVERSIDADE FEDERAL DE PELOTAS; GABRIEL S. CAMPOS, UNIVERSIDADE FEDERAL DE PELOTAS; VINÍCIUS S. JUNQUEIRA, UNIVERSIDADE FEDERAL DE VIÇOSA; HELENA B. COMIN, UNIVERSIDADE FEDERAL DE PELOTAS; BRUNA PENA SOLLERO, CENARGEN; LEANDRO L. CARDOSO; RODRIGO F. DA COSTA, UNIVERSIDADE FEDERAL DE PELOTAS; ARIONE A. BOLIGON, UNIVERSIDADE FEDERAL DE PELOTAS; MARCOS JUN ITI YOKOO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL.
Año:	2024
Referencia:	Journal of Animal Breeding and Genetics, v. 142, n. 1, p. 69-78, 2024.
Descripción:	This study utilized Bayesian inference in a genome-wide association study (GWAS) to identify genetic markers associated with traits relevant to the adap- tation of Hereford and Braford cattle breeds. We focused on eye pigmentation (EP), weaning hair coat (WHC), yearling hair coat (YHC), and breeding stand- ard (BS). Our dataset comprised 126,290 animals in the pedigree. Out of these, 233 sires were genotyped using high-density (HD) chips, and 3750 animals with medium-density (50 K) single-nucleotide polymorphism (SNP) chips. Employing the Bayes B method with a prior probability of π = 0.99, we identified and tagged single nucleotide polymorphisms (Tag SNPs), ranging from 18 to 117 SNPs de- pending on the trait. These Tag SNPs facilitated the construction of reduced SNP panels. We then evaluated the predictive accuracy of these panels in compari- son to traditional medium-density SNP chips. The accuracy of genomic predic- tions using these reduced panels varied significantly depending on the clustering method, ranging from 0.13 to 0.65. Additionally, we conducted functional enrich- ment analysis that found genes associated with the most informative SNP mark- ers in the current study, thereby providing biological insights into the genomic basis of these traits.
Thesagro:	Gado de Corte Gado Hereford Seleção
Palabras clave:	Gado Braford
Tipo de Material:	Artigo de periódico
Acceso:	openAccess
Aparece en las colecciones:	Artigo em periódico indexado (CENARGEN)