Title:	Steady State Free Precession NMR without Fourier Transform: Redefining the Capabilities of 19F NMR as a Discovery Tool.
Authors:	GAUTHIER, J. KOCK, F. DOWNEY, K. MORAES, T. ALMEIDA, L. S. MUIR, D. C. G. LETCHER, R. J. COLNAGO, L. A. KRISHNAMURTHY, K. MABURY, S. SIMPSON, A. J.
Affiliation:	UNIVERSITY OF TORONTO UNIVERSITY OF TORONTO SCARBOROUGH UNIVERSITY OF TORONTO SCARBOROUGH SÃO PAULO UNIVERSITY SÃO PAULO UNIVERSITY CANADA CENTRE FOR INLAND WATERS CARLETON UNIVERSITY LUIZ ALBERTO COLNAGO, CNPDIA CHEMPACKER LLC UNIVERSITY OF TORONTO UNIVERSITY OF TORONTO.
Date Issued:	2025
Citation:	Angewandte Chemie, v. 64, e202422971, 2025.
Pages:	9 p.
Description:	Abstract: The 2024 Zurich perfluorinated compounds (PFCs) summit reiterated the urgent need for non-selective analytical approaches for PFC detection. 19F NMR holds great potential, however, sensitivity limitations lead to long analysis times and/or the possibility of not detecting low concentration species. Steady State Free Precession (SSFP) NMR collects the signal in a steady state regime, allowing 100’s of acquisitions in the timespan of a single traditional NMR scan. Unfortunately, data truncation from SSFP leads to artifacts and spectral broadening with Fourier transform, hindering interpretation. When non-Fourier based time-domain analysis is used, namely, complete reduction to amplitude frequency tables (CRAFT), limitations of SSFP are eliminated while sensitivity gains are retained. This work introduces the combined approach, then applies it for the measurement of PFCs in environmental and biological samples. In all cases, the approach reduces analysis time from many hours to minutes and/or greatly increases the range of compounds detected. For example, when PFOA was spiked into human blood, the detection limit improved ~50-fold vs standard NMR, while in a standard mixture, the approach detected compounds missed by LC-MS/MS. The technique can be adapted to any nucleus providing a facile approach to reduce experiment time and improve sensitivity of NMR in general.
Keywords:	NMR scan
DOI:	10.1002/anie.202422971
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPDIA)