Título:	Detection of SNPs in bovine immune-response genes that may mediate resistance to the cattle tick Rhipicephalus (Boophilus) microplus.
Autoria:	ABATEPAULO, A. R. R. CAETANO, A. R. MENDES JÚNIOR, C. T. CARVALHO, W. A. FERREIRA, B. R. SANTOS, K. F. de M.
Afiliação:	A. R. R. Abatepaulo, Ribeirão Preto Medical School; Alexandre Rodrigues Caetano, Embrapa Recursos Genéticos e Biotecnologia; C. T. Mendes Jr, Ribeirão Preto Medical School; W. A. Carvalho, Ribeirão Preto Medical School; B. R. Ferreira, Ribeirão Preto Medical School; Isabel Kinney Ferreira de Miranda Santos, Embrapa Recursos Genéticos e Biotecnologia.
Ano de publicação:	2008
Referência:	Animal Genetics, v.39, p.328-332, 2008.
Conteúdo:	Source/description: Ticks cause serious losses in animal productivity. Bovine hosts express heritable, contrasting phenotypes when exposed to Rhipicephalus microplus. Bos indicus breeds are significantly more resistant to infestations than Bos taurus breeds. Animals in populations derived from crosses between these groups show varying levels of resistance, indicating a polygenic basis for the trait. Different breeds also develop qualitatively distinct immune responses against ticks and their tick-infested skin expresses significantly different levels of mRNA for the immune response genes studied herein. We examined genomic sequences of the genes TGFB1, CXCL10 (also known as IP-10), TNF, IFNG, CCL3 (also known as MIP-1a), IGF1 and CCL2 (also known as MCP-1) for the presence of breed-specific SNPs by comparing PCR-amplified genomic sequences from tick-resistant and tick-susceptible bovine breeds.
Thesagro:	Bovino
Palavras-chave:	SNPs Rhipicephalus (Boophilus) microplus
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em anais de congresso (CENARGEN)