Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/875214
Research center of Embrapa/Collection: Embrapa Informática Agropecuária - Artigo em periódico indexado (ALICE)
Date Issued: 2009
Type of Material: Artigo em periódico indexado (ALICE)
Authors: HIGA, R. H.
TOZZI, C. L.
Additional Information: ROBERTO HIROSHI HIGA, FEEC/UNICAMP, CNPTIA; CLÉSIO LUIS TOZZI, FEEC/UNICAMP.
Title: Prediction of binding hot spot residues by using structural and evolutionary parameters.
Publisher: Genetics and Molecular Biology, Ribeirão Preto, v. 32, n. 3, p. 626-633, 2009.
Language: en
Keywords: Estrutura proteica
Interações proteína-proteína
Previsão de resíduos hot spots
Description: In this work, we present a method for predicting hot spot residues by using a set of structural and evolutionary parameters. Unlike previous studies, we use a set of parameters which do not depend on the structure of the protein in complex, so that the predictor can also be used when the interface region is unknown. Despite the fact that no information concerning proteins in complex is used for prediction, the application of the method to a compiled dataset described in the literature achieved a performance of 60.4%, as measured by F-Measure, corresponding to a recall of 78.1% and a precision of 49.5%. This result is higher than those reported by previous studies using the same data set.
NAL Thesaurus: Protein structure
Prediction
Data Created: 2011-02-01
Appears in Collections:Artigo em periódico indexado (CNPTIA)

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