Title:	Proteome-wide evolutionary analysis reveals lineage-specific adaptations and improves funtional annotation of Schistosoma mansoni proteins.
Authors:	SILVA, L. MARCET-HOUBEN, M. NAHUM, L. ZERLOTINI, A. GALBADÓN, T. OLIVEIRA, G.
Affiliation:	LARISSA SILVA, Centro de Pesquisas René Rachou; MARINA MARCET-HOUBEN, Fiocruz; LAILA NAHUM, Centro de Pesquisas René Rachou; ADHEMAR ZERLOTINI NETO, CNPTIA; TONI GALBADÓN; GUILHERME OLIVEIRA.
Date Issued:	2012
Citation:	In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 8., 2012, Campinas. Abstract book... Ribeirão Preto: AB3C, 2012.
Pages:	Não paginado.
Description:	In this context, comparative proteomic analysis can shed new light on the evolutionary processes that shaped hostparasite interaction over evolutionary time. Taking advantage of the benefits provided by a largescale phylogenetic analysis, in the present work, we reconstructed the evolutionary history of each protein encoded in the S. mansoni genome in comparison with other 12 taxa to gain insights into lineage-specific evolutionary events, potentially related to the parasitic lifestyle, as well as to improve functional annotation. Results The collection of trees reconstructed in this work includes 7,964 phylogenies, which comprises the evolutionary histories of all parasite proteins and their homologs across 12 other organisms. This analysis allowed a deeper understanding of genomic complexity and evolutionary adaptations to a parasitic lifestyle.
Thesagro:	Genoma Schistosoma Mansoni
NAL Thesaurus:	Proteome Genomics
Keywords:	Proteoma
Notes:	X-MEETING 2012.
Type of Material:	Resumo em anais e proceedings
Access:	openAccess
Appears in Collections:	Resumo em anais de congresso (CNPTIA)