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http://www.alice.cnptia.embrapa.br/alice/handle/doc/1101203
Título: | A comprehensive manually-curated compendium of bovine transcription factors. |
Autoria: | SOUZA, M. M. de ZERLOTINI NETO, A. GEISTLINGER, L. TIZIOTO, P. C. TAYLOR, J. F. ROCHA, M. I. P. DINIZ, W. J. S. COUTINHO, L. L. REGITANO, L. C. de A. |
Afiliação: | Marcela M. de Souza, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; Ludwig Geistlinger, FAPESP; Polyana C. Tizioto, NGS Genomic Solution; Jeremy F. Taylor, University of Missouri; Marina I. P. Rocha, UFSCar; Wellison J. S. Diniz, UFSCar; Luiz L. Coutinho, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
Ano de publicação: | 2018 |
Referência: | Scientific Reports, v.8, n.13747, p.1-12, jan. 2018. |
Conteúdo: | Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species. |
NAL Thesaurus: | Gene expression regulation |
Palavras-chave: | DNA bovine Gene expression in cattle |
Digital Object Identifier: | 10.1038/s41598-018-32146-2 |
Tipo do material: | Artigo de periódico |
Acesso: | openAccess |
Aparece nas coleções: | Artigo em periódico indexado (CPPSE) |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ComprehensiveManuallyCurated.pdf | 3,34 MB | Adobe PDF | Visualizar/Abrir |