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dc.contributor.authorSOUZA, M. M. de
dc.contributor.authorZERLOTINI NETO, A.
dc.contributor.authorGEISTLINGER, L.
dc.contributor.authorTIZIOTO, P. C.
dc.contributor.authorTAYLOR, J. F.
dc.contributor.authorROCHA, M. I. P.
dc.contributor.authorDINIZ, W. J. S.
dc.contributor.authorCOUTINHO, L. L.
dc.contributor.authorREGITANO, L. C. de A.
dc.date.accessioned2018-12-22T23:33:30Z-
dc.date.available2018-12-22T23:33:30Z-
dc.date.created2018-12-20
dc.date.issued2018
dc.identifier.citationScientific Reports, v. 8, p. 1-12, 2018.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1102174-
dc.descriptionTranscription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectDNA bovino
dc.subjectExpressão gênica
dc.subjectGene expression in cattle
dc.titleA comprehensive manually-curated compendium of bovine transcription factors.
dc.typeArtigo de periódico
dc.date.updated2019-02-05T11:11:11Zpt_BR
dc.subject.nalthesaurusGene expression regulation
dc.description.notesArticle number: 13747. Na publicação: Adhemar Zerlotini, Luciana C. A. Regitano.
riaa.ainfo.id1102174
riaa.ainfo.lastupdate2019-02-05 -02:00:00
dc.identifier.doi10.1038/s41598-018-32146-2
dc.contributor.institutionMARCELA M. DE SOUZA, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; LUDWIG GEISTLINGER, CPPSE; POLYANA C. TIZIOTO, NGS Genomic Solution; JEREMY F. TAYLOR, University of Missouri; MARINA I. P. ROCHA, UFSCar; WELLISON J. S. DINIZ, UFSCar; LUIZ L. COUTINHO, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
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