Title:	A comprehensive manually-curated compendium of bovine transcription factors.
Authors:	SOUZA, M. M. de ZERLOTINI NETO, A. GEISTLINGER, L. TIZIOTO, P. C. TAYLOR, J. F. ROCHA, M. I. P. DINIZ, W. J. S. COUTINHO, L. L. REGITANO, L. C. de A.
Affiliation:	MARCELA M. DE SOUZA, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; LUDWIG GEISTLINGER, CPPSE; POLYANA C. TIZIOTO, NGS Genomic Solution; JEREMY F. TAYLOR, University of Missouri; MARINA I. P. ROCHA, UFSCar; WELLISON J. S. DINIZ, UFSCar; LUIZ L. COUTINHO, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Date Issued:	2018
Citation:	Scientific Reports, v. 8, p. 1-12, 2018.
Description:	Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
NAL Thesaurus:	Gene expression regulation
Keywords:	DNA bovino Expressão gênica Gene expression in cattle
DOI:	10.1038/s41598-018-32146-2
Notes:	Article number: 13747. Na publicação: Adhemar Zerlotini, Luciana C. A. Regitano.
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPTIA)