Título:	A comprehensive manually-curated compendium of bovine transcription factors.
Autoria:	SOUZA, M. M. de ZERLOTINI NETO, A. GEISTLINGER, L. TIZIOTO, P. C. TAYLOR, J. F. ROCHA, M. I. P. DINIZ, W. J. S. COUTINHO, L. L. REGITANO, L. C. de A.
Afiliação:	MARCELA M. DE SOUZA, UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; LUDWIG GEISTLINGER, CPPSE; POLYANA C. TIZIOTO, NGS Genomic Solution; JEREMY F. TAYLOR, University of Missouri; MARINA I. P. ROCHA, UFSCar; WELLISON J. S. DINIZ, UFSCar; LUIZ L. COUTINHO, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Ano de publicação:	2018
Referência:	Scientific Reports, v. 8, p. 1-12, 2018.
Conteúdo:	Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
NAL Thesaurus:	Gene expression regulation
Palavras-chave:	DNA bovino Expressão gênica Gene expression in cattle
Digital Object Identifier:	10.1038/s41598-018-32146-2
Notas:	Article number: 13747. Na publicação: Adhemar Zerlotini, Luciana C. A. Regitano.
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPTIA)