Title:	Protection efficacy of the rLTB-R1 chimera against experimental swine mycoplasmal pneumonia.
Authors:	FERREIRA, M. R. A. FINGER, P. F. MAGALHÃES, C. G. CUNHA, C. E. P. da MOREIRA JÚNIOR, C. KICH, J. D. MORES, M. A. Z. MOREIRA, A. N. DELLAGOSTIN, O. A. CONCEIÇÃO, F. R.
Affiliation:	MARCOS ROBERTO ALVES FERREIRA, UFPel; PAULA FONSECA FINGER, UNIPAMPA; CAROLINA GEORG MAGALHÃES, UFPel; CARLOS EDUARDO POUEY DA CUNHA, UFPel; CLÓVIS MOREIRA JÚNIOR, UFPel; JALUSA DEON KICH, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; ÂNGELA NUNES MOREIRA, UFPel; ODIR ANTONIO DELLAGOSTIN, UFPel; FABRICIO ROCHEDO CONCEIÇÃO, UFPel.
Date Issued:	2019
Citation:	Acta Scientiae Veterinária, v. 47, n. 1660, 2019.
Description:	Abstract: Mycoplasma hyopneumoniae is the etiological agent of the Swine Mycoplasmal Pneumonia (SMP), one of the most economically significant diseases in the swine industry worldwide. Commonly used vaccines for SMP control consist of inactivated whole cells (bacterins). These vaccines are efficacious against M. hyopneumoniae challenge, but do not prevent colonization by the pathogen or completely eliminate pneumonia. P97 adhesin is conserved in the M. pneumoniae virulent strains, therefore it is an attractive target to be used in recombinant vaccines against M. hyopneumoniae. The aim of the present study was to evaluate protection afforded by rLTB-R1, a recombinant chimera composed by LTB fused with the R1 repeat region of P97 adhesin of M. hyopneumoniae, in specific-pathogen-free (SPF) piglets vaccinated by intranasal or intramuscular route and challenged with a pathogenic strain of M. hyopneumoniae.
Thesagro:	Pneumonia Micoplasma Vacina Suinocultura
NAL Thesaurus:	Mycoplasma hyopneumoniae Vaccination Adhesins
Keywords:	Pneumonia micoplasmática suína Vacinação mucosa Adesina P97 LTB
DOI:	10.22456/1679-9216.90862
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPSA)