Title:	Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family.
Authors:	FRAUCHES, N. S. MONTENEGRO, J. AMARAL, T. ABREU, J. P. LAIBER, G. JORGE JUNIOR BORGUINI, R. G. SANTIAGO, M. C. P. de A. PACHECO, S. NAKAJIMA, V. M. GODOY, R. L. de O. TEODORO, A. J.
Affiliation:	Nayara Simas Frauches, UNIRIO Júlia Montenegro, UNIRIO Thuane Amaral, UNIRIO Joel Pimentel Abreu, UNIRIO Gabriela Laiber, UNIRIO Jorge Junior, UFRJ RENATA GALHARDO BORGUINI, CTAA MANUELA CRISTINA P DE A SANTIAGO, CTAA SIDNEY PACHECO, CTAA Vania Mayumi Nakajima, UFF RONOEL LUIZ DE OLIVEIRA GODOY, CTAA Anderson Junger Teodoro, UNIRIO.
Date Issued:	2021
Citation:	Molecules, v. 26, n. 564 , 2021. p. 1-16.
Description:	There is a significant indication of the beneficial health effects of fruit rich diets. Fruitsof native plant species have noticeably different phytochemicals and bioactive effects. The aim ofthis work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ),jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and theirinfluence on antioxidant activityin vitroand antiproliferative effects on human colon adenocarci-noma cells. According to the results, dried peel powders (DP) have a high anthocyanin content,phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD).M.jaboticabadried peel powder extract had a higher total anthocyanin and phenolic compounds content(802.90±1.93 and 2152.92±43.95 mg/100 g, respectively). A reduction in cell viability of HT-29cells after treatment withM. jaboticabaextracts (DP-MJ and FD-MJ) was observed via MTT assay.Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SMhad an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cellsin relation to the control group. The findings of this study highlight the potential of peel powdersfromMyrtaceaefruits as an important source of natural antioxidants and a protective effect againstcolon adenocarcinoma
Thesagro:	Jabuticaba
NAL Thesaurus:	Bioactive compounds
Keywords:	Colon cancer Malay-apple Jamun-berry Myrtaceae fruits
DOI:	https://doi.org/10.3390/molecules26030564
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CTAA)