Título:	Myrciaria jaboticaba fruit peel: Bioactive composition as determined by distinct harvest seasons and in vitro anti-cancer activity.
Autoria:	NASCIMENTO, R. de P. do RIZZATO, J. S. POLEZI, G. BOUGHANEM, H. WILLIAMS, N. G. BORGUINI, R. G. SANTIAGO, M. C. P. de A. MAROSTICA JUNIOR, M. R. PARRY, L.
Afiliação:	ROBERTO DE PAULA DO NASCIMENTO, UNIVERSIDADE ESTADUAL DE CAMPINAS; JULIA SOTO RIZZATO, UNIVERSIDADE ESTADUAL DE CAMPINAS; GABRIELE POLEZI, UNIVERSIDADE ESTADUAL DE CAMPINAS; HATIM BOUGHANEM, CARDIFF UNIVERSITY; NON GWENLLIAN WILLIAMS, CARDIFF UNIVERSITY; RENATA GALHARDO BORGUINI, CTAA; MANUELA CRISTINA P DE A SANTIAGO, CTAA; MARIO ROBERTO MAROSTICA JUNIOR, UNIVERSIDADE ESTADUAL DE CAMPINAS; LEE PARRY, CARDIFF UNIVERSITY.
Ano de publicação:	2024
Referência:	Plants, v. 13, n. 20, p. 2907, 2024.
Conteúdo:	Jaboticaba (Myrciaria jaboticaba) is a recognizable and unique crop from Brazil. The fruit’s byproducts are currently being studied, given their bioactive composition and promising anti-cancer potential. It is not evident, however, if different harvesting seasons can modify the chemical profile and antioxidant capacity of jaboticaba fruit fractions. Furthermore, as there is limited data for jaboticaba’s anti-proliferative effects, additional assessments are required to improve the robustness of these findings. Therefore, this study aimed to determine the composition of the peel of jaboticaba collected in two periods (May—off-season, sample 1—and August–October—peak season, sample 2) and test the peel’s richest anthocyanin sample against colorectal cancer (CRC) cell lines. To accomplish this, proximate, spectrophotometric, and chromatographic analyses were performed in two freeze-dried samples; and anti-proliferative and/or colony-forming assays were carried out in Caco-2, HT29, and HT29-MTX cells. As a result, sample 2 showed the highest levels of polyphenols overall, including flavonoids and anthocyanins. This sample displayed significative higher contents of cyanidin-3-O-glucoside (48%) and delphinidin-3-O-glucoside (105%), in addition to a superior antioxidant capacity (23% higher). Sample 1 showed higher amounts of total protein, gallic acid (20% higher), and specific carotenoids. An aqueous extract from sample 2 was tested against CRC, showing anti-proliferative effects for Caco-2 cells at 1 and 2 mg/mL concentrations, with IC50 values of 1.2–1.3 mg/mL. Additionally, the extract was able to inhibit cell colony formation when tested at both low and high concentrations. In conclusion, jaboticaba collected in the main season stands out regarding its polyphenol composition and holds potential against cancer cell growth.
Thesagro:	Jabuticaba Casca Composição Química Antocianina Câncer Espectrofotometria Cromatografia Flavonóide Myrciaria Jaboticaba
NAL Thesaurus:	Byproducts Anthocyanins
Palavras-chave:	Agro-industrial byproduct Anti-colony-forming activity Anti-proliferative action Caco-2 cells
Digital Object Identifier:	https://doi.org/10.3390/plants13202907
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CTAA)