Title:	Biobased composite fibrous membrane using PLA and lignin carbon dots Fabricated via solution blow spinning for wound dressing application
Authors:	ROSSI, P. F. SANTOS, D. M. dos. MARAGON, C. A. TEODORO, K. B. R. COSTA. C. S. INADA, N. M. CORREA, D. S. ORÉFICE, R. L.
Affiliation:	PATRÍCIA F. ROSSI, FEDERAL UNIVERSITY OF MINAS GERAIS (UFMG); DANILO M. DOS SANTOS, UNIVERSIDADE DE SÃO PAULO; CRISIANE A. MARANGON, UNIVERSIDADE DE SÃO PAULO; KELCILENE BRUNA TEODORO COSTA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; CAMILA S. COSTA, UNIVERSITY OF SAO PAULO (USP); NATALIA M. INADA, UNIVERSITY OF SAO PAULO (USP); DANIEL SOUZA CORREA, CNPDIA; RODRIGO L. ORÉFICE, FEDERAL UNIVERSITY OF MINAS GERAIS (UFMG).
Date Issued:	2025
Citation:	Materials Today Communications, 42
Description:	Traditional wound dressings have limitations in terms o their antibacterial and anti-infammatory properties, as well as their ability to maintain a moist wound environment. Addressing these shortcomings in conventional medical materials is essential or advancing wound healing in clinical applications. Additionally, biodegradable polymeric wound dressings have gained signicant attention as a promising solution to reduce the environmental impact associated with the disposal o wound dressings. In this study, we developed a nanoengineered wound dressing abricated by solution blow spinning technique by using poly(lactic acid) (PLA) brous mats that integrate lignin-derived carbon dots (LCDots), urther enhanced with curcumin. This unique combination leverages the antimicrobial and antioxidant properties o curcumin alongside the electrical and photoluminescent eatures o LCDots, creating a multiunctional dressing with enhanced wound-healing capabilities. The bioactive compounds lignin carbon dots and curcumin were incorporated into the wound dressing to provide antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. Besides, in vitro experiments have demonstrated the superior biocompatibility o these wound dressing platorms towards neonatal human dermal broblast cell lines (HDFn). Furthermore, these brous mats did not exhibit contact and adhesion o microorganisms according to the microbial penetration test. Additionally, the composite brous membrane exhibited avorable hydrophilic properties and mechanical strength, making it a promising candidate or multiunctional wound dressings. Finally, it can be combined with regenerative therapies to exploit their photoluminescent and electrical properties as a stimulus or wound healing
NAL Thesaurus:	Curcumin
Keywords:	Solution blow spinning Lignin carbon dots Antibacterial activity Wound dressings Biomaterial Electrical impedance
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPDIA)