Title:	Antimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin‑controlled release.
Authors:	BERNARDI, B. MALAFATTI, J. O. D. MOREIRA, A. J. NASCIMENTO, A. C. A. LIMA, J. B. VERMEERSCH, L. A. F. PARIS, E. C.
Affiliation:	FEDERAL UNIVERSITY OF SÃO CARLOS; SÃO PAULO STATE UNIVERSITY (UNESP); FEDERAL UNIVERSITY OF SÃO CARLOS; SÃO PAULO STATE UNIVERSITY (UNESP); ELAINE CRISTINA PARIS, CNPDIA.
Date Issued:	2025
Citation:	Discover Nano, v. 20, 8, 2025.
Pages:	15 p.
Description:	Multifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric bers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 ± 8 m2 g−1 ), high crystallinity and particles with a diameter of up to 100 nm were produced under optimized synthesis conditions (100 °C/4 h). Zeolites were incorporated into polymeric nanobers to be a cloxacillin (CLX) carrier in wound treatment, using electrospinning as an ecient synthesis method. The bers produced showed good mechanical resistance and the ncorporation of CLX was proven by assays to inhibit the growth of Staphylococcus aureus bacteria. The controlled release of CLX in dierent pH conditions, which simulate the wound environment, was carried out for up to 229 h, achieving a released CLX concentration of up to 6.18 ± 0.02 mg L−1 . These results prove that obtaining a hybrid fiber (polymer-zeolite) to incorporate drugs to be released in a controlled manner was successfully achieved. The bactericidal activity of this material shows that its use for measured applications could be an alternative to conventional methods.
Keywords:	Antimicrobial Electrospun Faujasite Polycaprolactone
DOI:	https://doi.org/10.1186/s11671-024-04161-y
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPDIA)