Title:	Synthesis of the tetracyclic nucleus of epi-Sarcophytin, and evaluation of its activity.
Authors:	FERREIRA, M. L. MODA, T. BROCKSOM, U. BROCKSOM, T. J.
Affiliation:	MARIA LUCIA FERREIRA, CNPF.
Date Issued:	2003
Citation:	In: BRAZILIAN MEETING ON ORGANIC SYNTHESIS, 10., 2003, São Pedro. [Abstracts...]. Campinas: Unicamp, 2003.
Description:	We have been investigating the synthesis of (+)-Sarcophytin o (3) and correlated compounds, and also studying their possible phytotoxic activity. For the synthesis of the tetracyclic nucleus of the C-1-epimer of (+)-3, we chose the halocyclization reaction (NBS in THF/H>20) of Diels-Alder (o) cycloadduct (+)-1, producing compound (+)-2 in 81% yield. Thus (+)-2 can now be obtained in six steps from the cheap chiron (R)-(+)-pulegone in 24% overall yield.
Keywords:	Sarcophytin Diels-Alder Phytotoxic
Type of Material:	Resumo em anais e proceedings
Access:	openAccess
Appears in Collections:	Resumo em anais de congresso (CNPF)